摘要
目的 探讨儿童幽门螺杆菌(HP)药敏实验结果及耐药影响因素。方法 回顾性分析嘉兴市妇幼保健院2015年1月至2020年1月收治的^(13)C呼气实验阳性HP感染儿童例临床资料,记录HP耐药情况,同时采用单因素和多因素评价HP耐药独立危险因素。结果 492例患儿中培养出HP菌株共348株,药敏实验结果显示,对克拉霉素、甲硝唑、四环素和阿莫西林均敏感者有2株(占0.57%),单一抗菌药物耐药、双重耐药、三重耐药及四重耐药者分别有150株(占43.10%)、188株(占54.02%)、4株(占1.15%)和4株(1.15%)。Logistic回归模型分析结果显示,既往接受过规范HP根除治疗失败是HP感染患儿克拉霉素耐药发生独立危险因素(OR=0.10,95%CI:0.03-0.29)。结论 HP感染患儿出现克拉霉素、甲硝唑及双重耐药风险较高;既往接受过规范HP根除治疗失败与克拉霉素耐药发生独立相关。
Objective To investigate the drug sensitivity test results and drug resistance risk factors in children with HP infection. Methods The clinical data of 492 HP infected children with positive ^(13)C breath test from January 2015 to January 2020 in Jiaxing Maternal and Child Health Hospital were retrospectively analyzed. The drug resistance was recorded,and the independent risk factors of HP resistance were evaluated by univariate and multivariate analysis. Results A total of 348 HP strains were isolated from 492 children. The drug sensitivity test showed that the sensitivity count of all antibiotics(included Clarithromycin,Metronidazole,Tetracycline and Amoxycilin)was 2(0.57%)the count of single antibiotic resistance,double resistance,triple resistance and quadruple resistance were 150(43.10%),188(54.02%),4(1.15%) and 4(1.15%),The result of binary logistic regression model analysis showed that failure of previous HP eradication treatment was an independent risk factor for c larithromycin resistance in children with HP infection(OR=0.10,95%CI:0.03-0.29). Conclusion Children with HP infection have a higher risk of clarithromycin,metronidazole and double drug resistance. The failure of previous HP eradication therapy was independently related to clarithromycin resistance.
作者
李炜
陶建华
郭佳妮
张解宁
金佩丽
LI Wei;TAO Jian-hua;GUO Jia-ni;ZHANG Jie-ning;JIN Pei-li(Department of Pediatrics,Jiaxing Maternal and Child Health Care Hospital,Zhejiang Jiaxing 314051,China)
出处
《临床药物治疗杂志》
2022年第4期60-63,共4页
Clinical Medication Journal
关键词
幽门螺杆菌
药敏实验
耐药
影响因素
helicobacter pylori
infection
drug sensitivity test
drug resistance
risk factors
