摘要
目的探讨术前玻璃酸钠滴眼液联用重组牛碱性成纤维细胞生长因子(rbBFG)对白内障合并干眼的手术疗效。方法选择2019年1月-2021年6月白内障合并干眼患者96例(丽水市第二人民医院34例,丽水市中心医院62例),随机分为对照组和联用组各48例。对照组术前7天给予玻璃酸钠滴眼液局部用药,联用组在对照组基础上联用rbBFG治疗,两组均行超声乳化术+晶体植入术。比较两组治疗前与术后30天的临床症状、眼表功能、泪液炎症因子及氧化应激水平。结果治疗前,临床症状、眼表功能、泪液炎症因子及氧化应激水平差异均无统计学意义(P>0.05),治疗后,联用组临床症状评分明显低于对照组,差异有统计学意义(P<0.05);治疗后,联用组眼表疾病指数、基础泪液分泌试验结果、泪膜破裂时间以及角膜荧光染色评分改善均较对照组显著,组间比较差异具有统计学意义(P<0.05);治疗后,联用组TNF-α、IL-6及丙二醛(MDA)水平较对照组低,总抗氧化能力(TAC)及超氧化物歧化酶(SOD)水平较对照组高,组间比较差异具有统计学意义(P<0.05)。结论术前应用玻璃酸钠滴眼液和rbBFG能改善白内障合并干眼患者术后的临床症状及眼表功能,减轻其炎症及氧化应激反应。
Objective To investigate the effect of preoperative sodium hyaluronate eye drops combined with recombinant bovine basic fibroblast growth factor.Methods 96 patients with cataract and dry eye were randomly divided into control group and combined group,with 48 cases in each group.The control group was treated with sodium hyaluronate eye drops 7 days before operation,and the combined group was treated with rbbfg on the basis of the control group.Both groups were treated with phacoemulsification+lens implantation.The clinical effects of the two groups before treatment and 30 days after operation were compared Bed symptoms,ocular surface function,tear inflammatory factors and oxidative stress levels.Results Before treatment,clinical symptoms,ocular surface function There was no significant difference in the levels of tear inflammatory factors and oxidative stress(P>0.05).After treatment,the clinical symptom score of the combined group was significantly lower than that of the control group(P<0.05);after treatment,the improvement of ocular surface disease index,basic tear secretion test results,tear film rupture time and corneal fluorescence staining score in the combined group were significantly higher than those in the control group(P<0.05);after treatment,The levels of TNF-α、IL-6 and malondialdehyde(MDA)were in the combined group was significantly lower than that in the control group(P<0.05),and the levels of total antioxidant capacity(TAC)and superoxide dismutase(SOD)were higher than those in the control group.The difference between the groups was statistically significant.Conclusion The preoperative application of sodium hyaluronate eye drops and rbbfg can improve the clinical symptoms and ocular surface function of patients with cataract complicated with dry eye,and reduce their inflammation and oxidative stress.
作者
张少威
应佳
张秀珍
ZHANG Shaowei;YING Jia;ZHANG Xiuzhen(Lishui Second People's Hospital,Lishui 323000,China;Lishui Central Hospital,Lishui 323000,China)
出处
《浙江实用医学》
2021年第4期296-299,共4页
Zhejiang Practical Medicine
