摘要
促炎因子广泛存在于中枢及外周组织中,是参与神经系统变性疾病发生过程的重要细胞因子之一。近年来发现,由于其可与炎性通路、氧化应激过程、铁死亡等关联性靶标作用参与帕金森病(PD)的发生发展,已成为研究PD发病机制的切入点。而随着促炎因子的研究在中医药药理学的逐渐深入,为PD的临床治疗提供了有力的依据。该文通过总结近年来促炎因子与PD的发生过程及其中医药干预的临床治疗,兹以综述,为PD的病机学研究及治疗提供新思路。
Proinflammatory factors widely exist in central and peripheral tissues. They are one of the important cytokines involved in the occurrence of degenerative diseases of the nervous system. In recent years,it has been found that it can be related to inflammatory pathway, oxidative stress process, Iron death and other related targets are involved in Parkinson disease(PD). The occurrence and development of PD has become the entry point to study the pathogenesis of PD. With the gradual infiltration of the research on proinflammatory factors in traditional Chinese medicine pharmacology, it provides a strong basis for the clinical treatment of PD. This paper summarizes the occurrence process of proinflammatory factors and PD and the clinical treatment of medical intervention in recent years,so as to provide new ideas for the pathogenesis research and treatment of PD.
作者
罗荣卿
胡玉英
LUO Rongqing;HU Yuying
出处
《新中医》
CAS
2022年第7期18-22,共5页
New Chinese Medicine
基金
国家自然科学基金项目(81960842)
广西高等学校高水平创新团队及卓越学者计划项目(桂教人才[2020]6号)
广西中医药大学“岐黄工程”高层次人才团队培育项目(2018003)。
关键词
帕金森病
促炎因子
多途径
中医药治疗
综述
Parkinson disease
Proinflammatory factors
Multiple approaches
Traditional Chinese medicine
Overview
