褪黑素基于线粒体保护治疗心肌梗死的研究进展被引量：1

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摘要近年来,再灌注治疗显著增加了急性心肌梗死患者的存活率。尽管如此,心肌缺血再灌注损伤与心肌梗死后的不良重构仍然严重影响了患者的治疗和预后效果。线粒体在心肌缺血再灌注与心肌重构中起着至关重要的作用,是心肌梗死治疗的重要靶标。褪黑素是一种天然的抗氧化剂,对线粒体的保护作用已得到多方验证。本文从褪黑素对线粒体的保护作用入手,介绍了褪黑素治疗心肌梗死的研究进展。

作者张子睿吕婷婷李尚孙岚

机构地区中国医学科学院北京协和医学院药物研究所药物筛选中心

出处《江苏大学学报（医学版）》 CAS 2022年第3期207-212,共6页 Journal of Jiangsu University：Medicine Edition

基金国家自然科学基金面上项目(82070056,81670456)。

关键词心肌梗死褪黑素线粒体线粒体自噬线粒体通透性转换孔细胞焦亡

分类号 R542.22 [医药卫生—心血管疾病]

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参考文献2

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2颜骏,张浩,王好,陶艾彬,姚永伟,张国辉,芮涛.线粒体活性氧在心肌成纤维细胞NLRP3炎症小体激活中的作用[J].江苏大学学报（医学版）,2020,30(3):243-247. 被引量：2

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