摘要
目的探讨围绝经期女性特发性良性阵发性位置性眩晕(iBPPV)与骨代谢生化指标之间的关系。方法选取围绝经期iBPPV患者105例作为病例组,随访1年,依据有无复发分为未复发组85例,复发组20例;并选取同期围绝经期健康女性50例作为对照组;对比三组血清雌二醇、25-羟维生素D、血钙浓度、Ⅰ型胶原氨基端延长肽(P1NP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、骨钙素水平,对围绝经期iBPPV患者血清雌二醇与骨代谢生化指标之间的关系进行Pearson相关分析。结果①对照组雌二醇、血钙浓度与25-羟维生素D水平明显高于未复发组和复发组,差异均有统计学意义(均为P<0.05);对照组P1NP、β-CTX、骨钙素水平与未复发组和复发组差异均无统计学意义(均为P>0.05)。复发组雌二醇、血钙浓度与25-羟维生素D水平明显低于未复发组,差异均有统计学意义(均为P<0.05);②围绝经期iBPPV患者血清中雌二醇与P1NP、骨钙素、血钙浓度及25-羟维生素D水平均呈明显正相关关系(分别为r=0.775,r=0.583,r=0.630,r=0.674,均为P<0.01),与β-CTX水平呈明显负相关关系(r=-0.717,P<0.01);③Logistic回归分析结果显示复位次数(OR=13.091)、SDS评分(OR=17.875)、就诊时眩晕时间(OR=4.800)、雌二醇(OR=0.859)、血钙浓度(OR=0.000)及25-羟维生素D(OR=0.676)为围绝经期女性iBPPV复发的易感因素。结论血清中雌二醇、血钙浓度和25-羟维生素D水平下降的围绝经期女性易发生iBPPV,且更易复发。
Objective To investigate the relationship between idiopathic benign paroxysmal positional vertigo(iBPPV)and bone metabolism biochemical index in perimenopausal women.Methods A total of 105 perimenopausal iBPPV patients were selected as the case group,followed up for 1 year,and divided into the non-recurrence group(85 cases)and the recurrence group(20 cases)according to the presence or absence of recurrence.In addition,50 healthy perimenopausal women were selected as the control group.Then compared three groups of blood serum estradiol,25-hydroxyl vitamin D,calcium concentration,collagen typeⅠamino end to extend the peptide P1NP,collagen typeⅠcarboxyl end beta peptide beta special sequenceβ-CTX,osteocalcin level.Pearson correlation was used to analyze the relationship between serum estradiol and bone metabolism biochemical indexes in perimenopausal iBPPV patients.Results①The concentrations of estradiol and serum calcium and the levels of 25-hydroxyvitamin D in the control group were significantly higher than those in the non-recurrence group and the recurrence group,with statistically significant differences(All P<0.05).The levels of P1NP,β-CTX and osteocalcin in the control group were not significantly changed from those in the non-recurrent group,nor were they significantly different from those in the recurrent group,and the differences were not statistically significant(all P>0.05).The concentrations of estradiol and serum calcium and the levels of 25-hydroxyvitamin D in the recurrence group were significantly lower than those in the non-recurrence group,and the differences were statistically significant(all P<0.05).②In the case group of perimenopausal iBPPV patients,the serum estradiol was positively correlated with P1NP,osteocalcin,serum calcium concentration and 25-hydroxyvitamin D level(r=0.775,r=0.583,r=0.674,P<0.01),and negatively correlated withβ-CTX level(r=-0.717,P<0.01).③Logistic regression analysis results showed reduction times(OR=13.091,95%CI 3.706-46.238),SDS score(OR=17.875,95%CI 5.535~57.727),time of vertigo during medical consultation(OR=4.800,95%CI 2.144-10.745),estradiol(OR=0.859,95%CI 0.749~0.985),and blood calcium concentration OR=0.000,95%CI Both 0.000~0.002 and 25-hydroxyvitamin D(OR=0.676,95%CI 0.546~0.838)were risk factors for iBPPV recurrence in perimenopausal women.Conclusion Perimenopausal women with reduced serum estradiol,serum calcium concentration,and 25-hydroxyvitamin D levels are prone to iBPPV and relapse.
作者
王田
邢巍巍
Wang Tian;Xing Weiwei(Department of Otolaryngology Head and Neck Surgery,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou,121000,China)
出处
《听力学及言语疾病杂志》
CAS
CSCD
北大核心
2022年第3期244-248,共5页
Journal of Audiology and Speech Pathology
关键词
围绝经期
特发性良性阵发性位置性眩晕
雌激素
骨代谢生化指标
Perimenopause
Idiopathic benign paroxysmal positional vertigo(iBPPV)
Estrogen
Bone metabolism biochemical index