摘要
帕金森病(Parkinson disease,PD)是最常见的运动障碍性疾病。运动症状包括静止性震颤,强直和姿势障碍等,通常表现为不对称起病,且不对称在病程中持续存在。大量研究提示起病侧或受累重侧不同的PD患者间具有显著不同的特征,而对PD运动不对称受累这一重要临床特征背后的机制目前尚不清楚。现对运动不对称受累PD患者的影像特征进行综述,并探讨、分析可能导致该特征的相关因素,以进一步揭示运动不对称受累潜在的机制。综述文献发现双侧多巴胺能系统生理上的不对称,疾病状态下改变模式的不对称,亦或是利手因素,都是导致PD运动不对称受累的重要机制。
Parkinson disease(PD)is the most common movement disorder.The motor symptoms of PD include resting tremor,rigidity and akinesia,which may be presented at onset asymmetrically and persisted along the disease course.Many studies demonstrated distinct findings between PD patients with different onset side or different more affected side.However,the mechanism of this important characteristic has not been clearly explained yet.This article reviewed the imaging findings of PD patients with motor function asymmetrically and explored the probable factors causing this asymmetry in ordet to identify its underlying mechanisms in PD.We found that the physiological asymmetry of bilateral dopaminergic system,the asymmetric pathological involvement under disease condition,and the handedness factor,are all important mechanisms that leading to the asymmetric motor involvement in PD.
作者
吴晶晶
张敏鸣
WU Jingjing;ZHANG Minming(Department of Radiology,The Second Affiliated Hospital,Zhejiang University School of Medicine.No.88 Jiefang Road,Shangcheng District,Hangzhou 310009,China)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2022年第2期116-120,共5页
Chinese Journal of Nervous and Mental Diseases
关键词
帕金森病
神经影像
运动
功能偏侧性
不对称
异质性
多巴胺
Parkinson disease
Neuroimaging
Movement disorder
Functional laterality
Asymmetry
Heterogeneity
Dopamine
