摘要
目的 探讨阿芬太尼复合丙泊酚抑制双腔支气管插管反应的半数有效剂量。方法 拟行双腔支气管插管患者分为男性组和女性组,均给予丙泊酚(2.0 mg/kg)复合阿芬太尼静脉麻醉,采用Dixon序贯法纳入患者,Probit回归分析计算阿芬太尼抑制双腔支气管插管反应的半数有效剂量(median effective dose,ED50)及其95%置信区间。结果 男性组ED50及其95%置信区间为77.9(95%CI:34.4~92.9)μg/kg;女性组的ED50及其95%置信区间为66.7(95%CI:60.5~76.0)μg/kg,男性组大于女性组,差异有统计学意义(P <0.05)。结论 复合丙泊酚2 mg/kg时,阿芬太尼抑制双腔支气管插管反应的ED50存在性别差异。
Objective To evaluate the median effective dose of alfentanil combined with propofol for inhibiting double lumen bronchial intubation response.Methods Patients undergoing double-lumen bronchial intubation were assigned to male group and female group.All patients were given propofol 2.0 mg/kg combined with alfentanil intravenous anesthesia.Dixon sequential method was used to observe the effect of medication on patients.Probit regression analysis was used to calculate median effective dose(ED50)and 95% confidence interval(95%effective dose,ED95)of alfentanil for inhibition of response to dual-lumen bronchial intubation.Results The ED50and 95% confidence interval of male group were 77.9(34.4 ~ 92.9)μg/kg.The ED50and 95% confidence interval were 66.7(60.5 ~ 76.0)μg/kg in female group,and the difference was statistically significant(P < 0.05).Conclusion When combined with propofol 2 mg/kg,the ED50of alfentanil inhibiting double-lumen bronchial intubation response was 77.9 μg/kg and 66.7 μg/kg in male and female groups,and there was gender difference in the ED50of alfentanil inhibiting double-lumen bronchial intubation response.
作者
陈南瑾
梁文华
应婷婷
陈玲阳
蒋永泼
CHEN Nanjin;LIANG Wenhua;YING Tingting;CHEN Lingyang;JIANG Yongpo(Department of Anesthesiology,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou 317000,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2022年第7期889-892,共4页
The Journal of Practical Medicine
基金
浙江省医药卫生项目(编号:2022KY435)
台州市科技计划项目(编号:21ywb05)。
关键词
阿芬太尼
气管插管反应
半数有效剂量
性别
alfentanil
endotracheal intubation reaction
median effective dose
gender
