摘要
目的探讨芪龙胶囊联合氯吡格雷治疗急性脑梗死恢复期(气虚血瘀型)的临床疗效。方法纳入2020年10月—2021年3月在南阳市中心医院就诊的120例急性脑梗死恢复期患者,随机分为对照组(60例)和治疗组(60例)。对照组口服硫酸氢氯吡格雷片,2片/次,1次/d;在对照组的基础上,治疗组口服芪龙胶囊治疗,2粒/次,3次/d。两组均治疗4周。观察两组患者临床疗效,比较治疗前后两组患者神经缺损和生活能力,全血黏度和血浆黏度,超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平,及氧化应激骨桥蛋白(OPN)、丙二醛(MDA)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)水平。结果治疗后,对照组和治疗组临床有效率分别为85.00%、96.67%,差异有统计学意义(P<0.05)。治疗后,两组NIHSS评分较治疗前显著降低,而Barthel指数显著升高(P<0.05),且治疗组NIHSS和Barthel指数显著好于对照组(P<0.05)。治疗后,两组患者全血高切黏度、全血低切黏度和血浆黏度、hs-CRP、IL-6和TNF-α、OPN和MDA水平均显著降低,而SOD和GSH-Px水平显著升高(P<0.05),且治疗后治疗组这些指标水平显著好于对照组(P<0.05)。结论芪龙胶囊辅助治疗急性脑梗死恢复期(气虚血瘀型)具有较好的疗效,能显著提高患者的神经功能和生活自理能力,主要机制可能与改善血液流变学状况、减轻氧化应激反应和降低炎症状况有关。
Objective To investigate the clinical efficacy of Qilong Capsules combined with clopidogrel in treatment of acute cerebral infarction in recovery period(qixue and xueyu type).Methods Patients(120 cases)with acute cerebral infarction in recovery period(qixue and xueyu type)in Nanyang Central Hospital from October 2020 to March 2021 were randomly divided into control(60 cases)and treatment(60 cases)group.Patients in the control group were po administered with Clopidogrel Bisulfate Tablets,2 tablets/time,once daily.Patients in the treatment group were po administered with Qilong Capsules on the basis of the control group,2 grains/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical evaluation was evaluated,nerve defect and living ability,whole blood viscosity and plasma viscosity,the levels of hs-CRP,IL-6 and TNF-α,the levels of serum OPN,MDA,SOD and GSH-Px in two groups before and after treatment were compared.Results After treatment,the clinical effective rates of the control group and the treatment group were 85.00%and 96.67%respectively(P<0.05).After treatment,the NIHSS score in two groups was significantly lower than that before treatment,while the Barthel index was significantly higher(P<0.05),and the NIHSS and Barthel index in the treatment group were significantly better than those of the control group(P<0.05).After treatment,the whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity,the levels of OPN,MDA,hs-CRP,IL-6 and TNF-αin two groups were significantly decreased,while the levels of SOD and GSH-PX were significantly increased(P<0.05),and the levels of these indexes in the treatment group were significantly better than those in the control group(P<0.05).Conclusion Qilong Capsule has good curative effect in the adjuvant treatment of acute cerebral infarction in recovery period(qixue and xueyu type),can significantly improve the neurological function and self-care ability of patients,and the main mechanism may be related to improving hemorheology,reducing oxidative stress and reducing inflammation.
作者
李军
LI Jun(Department of Neurology,Nanyang Central Hospital,Nanyang 473000,China)
出处
《现代药物与临床》
CAS
2022年第4期831-835,共5页
Drugs & Clinic
