摘要
本文针对多肽物质的合成进展,进行了文献系统调研,发现常规合成多肽技术主要有固相合成法和α-氨基酸-N-羧基内酸酐(NCAs)法,前者是一种低肽序列的合成法,耗时长、成本高、产量低,后者则反应时间短、聚合度高、多肽缺少特定的序列。然而,以碳酸二甲酯为羰基化试剂,N-甲氧酰基氨基酸分子间靶向脱羧缩聚合成多肽新技术则在精准调控多肽序列中有明显成效。
In this paper,the progress of peptide synthesis was systematically investigated,and it was found that polypeptide conventional synthesis mainly includes the solid phase synthesis andα-amino acid-N-carboxylic anhydride method.The former case is a low polypeptide sequence synthesis method,and it is time-consuming,high cost and low output.The latter case has the short reaction time,high degree of polymerization but lack of specific sequence.However,using dimethyl carbonate as carbonylation reagent,the new synthesis technology is effective in accurately regulating polypeptide sequence which is based on N-methoxycarbonyl amino acids(N-MC-AC)intermolecular targeted decarboxylation to synthesize the polypeptide by polycondensation.
作者
田莉
耿庆信
彭日丽
李振环
Tian Li;Geng Qingxin;Peng Rili;Li Zhenhuan(Shandong Sishui Experimental Middle School,Shandong,273299;Central Hospital Affi liated to Shandong First Medical University,Shandong,250014;State Key Laboratory of Separation Membranes and Membrane Processes,School of Materials Science and Engineering,Tiangong University,Tianjin,300387)
出处
《当代化工研究》
2022年第9期155-157,共3页
Modern Chemical Research
基金
国家自然科学基金面上项目“DMC法合成α-氨基酸-N-羧酸酐及其定向酰基化和靶向关环催化机制研究”(项目编号:21676202)
天津市自然科学基金重点项目“高强度高韧性无熔缩聚苯硫醚砜纤维的可控制备及应用”(项目编号:2019JCJDJC37300)
山东省自然科学基金重点项目“本征阻燃和无融缩型PPSO功能纤维制备及其在毛精纺织物中的应用研究”(项目编号:ZR2020KE053)。
关键词
生物基化学品
碳酸酯
多肽合成
分子设计与合成
bio-based chemicals
carbonate
polypeptide synthesis
molecular design and synthesis
