摘要
目的研究不同美国国立卫生研究院(NIH)分型、症状严重程度慢性前列腺炎(CP)患者前列腺液中白细胞(WBC)、卵磷脂小体(SPL)、免疫球蛋白(Ig)及趋化因子水平变化及意义。方法前瞻性选取2019年1月至2020年12月该院收治的166例CP患者,根据NIH分型标准分为Ⅱ型组54例,ⅢA型组63例,ⅢB型组49例;根据国际慢性前列腺炎症状指数分为轻度组55例,中度组69例,重度组42例;另选取同期在该院进行体检的健康男性50例作为对照组。比较不同NIH分型、症状严重程度CP患者前列腺液中WBC、SPL、Ig及趋化因子水平变化。结果不同NIH分型CP患者WBC比较差异有统计学意义(P<0.05),SPL等级比较,差异均无统计学意义(P>0.05)。Ⅱ、ⅢA、ⅢB型组IgG、IgA、IgM、MCP-1、MIP-1α水平均高于对照组,差异均有统计学意义(P<0.05);不同NIH分型CP患者IgG、IgA、IgM水平比较,差异无统计学意义(P>0.05),而单核细胞趋化蛋白-1(MCP-1)、趋化因子巨噬细胞炎性蛋白-1α(MIP-1α)水平比较结果为Ⅱ型组高于ⅢA型组,ⅢA型组高于ⅢB型组,差异均有统计学意义(P<0.05)。不同症状严重程度CP患者WBC、SPL等级比较,差异均无统计学意义(P>0.05);重、中、轻度组IgG、IgA、IgM、MCP-1、MIP-1α水平均高于对照组,差异均有统计学意义(P<0.05);不同症状严重程度CP患者IgG、IgA、IgM、MCP-1、MIP-1α水平比较结果为重度组高于中度组,中度组高于轻度组,差异均有统计学意义(P<0.05)。结论前列腺液MCP-1、MIP-1α、Ig可用于评估CP患者症状严重程度,MCP-1、MIP-1α、WBC可用于评估CP患者NIH分型,而SPL在评估NIH分型和症状严重程度方面均无明显价值。
Objective To explore the changes and significance of different National Institutes of Health(NIH)types,symptom severity,white blood cell(WBC),lecithin body(SPL),immunoglobulin(Ig)and chemokine levels in the prostatic fluid of the patients with chronic prostatitis(CP).Methods A total of 166 patients with CP treated in this hospital from January 2019 to December 2020 were prospectively selected and divided into the typeⅡgroup(54 cases),typeⅢA group(63 cases)and typeⅢB group(49 cases)according to the NIH classification criteria;contemporaneous 50 healthy males undergoing the physical examination in this hospital were selected as the control group.The International Chronic Prostatitis Symptom Index is divided into 55 cases in the mild group,69 cases in the moderate group,and 42 cases in the severe group.In addition,50 healthy men who underwent physical examination in our hospital during the same period were selected as the control group.Compare the changes of WBC,SPL,Ig and chemokine levels in the prostate fluid of CP patients with different NIH types and symptom severity.Results There were significant differences in WBC among the CP patients with different NIH types of various groups(P<0.05),and there was no statistically significant difference among the different SPL grades(P>0.05).The levels of IgG,IgA,IgM,MCP-1,and MIP-1αin theⅡ,ⅢA,andⅢB groups were higher than those in the control group,and the differences were statistically significant(P<0.05);the IgG,IgA and IgM levels had no statistically significant differences among the CP patients with different NIH types(P>0.05),while the comparison results of MCP-1 and MIP-1αlevels showed that the typeⅡgroup was higher than the typeⅢA group,and the typeⅢA group was higher than the typeⅢB group,and the differences were statistically significant(P<0.05).The comparison of WBC and SPL levels had no statistically significant difference among the CP patients with different symptom severities in each group(P>0.05)The levels of IgG,IgA,IgM,MCP-1,and MIP-1αin the severe,moderate,and mild groups all were higher than those in the control group,and the differences were statistically significant(P<0.05);the comparison results of IgG,IgA,IgM,MCP-1,and MIP-1αlevels among the CP patients with different symptom severities showed that the severe group was higher than the moderate group,and the moderate group was higher than the mild group,and the differences were statistically significant(P<0.05).Conclusion Prostatic fluid MCP-1,MIP-1αand Ig could be used to assess the severity of symptoms in CP patients,MCP-1,MIP-1αand WBC could be used to assess the NIH type in the CP patients,while SPL has no obvious value in assessing the NIH type and the symptom severity.
作者
刁建军
吴波
张姝红
吴建军
敬浩
DIAO Jianjun;WU Bo;ZHANG Shuhong;WU Jianjun;JING Hao(Third Affiliated Hospital of Chengdu Medical College/Pidu District People′s Hospital,Chengdu,Sichuan 611730,China)
出处
《重庆医学》
CAS
2022年第10期1665-1669,共5页
Chongqing medicine
基金
四川省医学青年创新科研课题计划项目(Q20063)。
