摘要
目的探讨替罗非班联合经皮冠脉介入术应用于急性心梗患者的临床治疗中对其临床疗效的优化作用。方法选取84例2020年3月—2021年4月该院收治的急性心梗患者为研究对象,按照入院时间对其分为对照组与观察组,每组42例,其入院时间分别为2020年3—9月、2020年10月—2021年4月。对照组采用经皮冠脉介入术治疗,观察组在对照组的基础上采用替罗非班治疗,对比两组治疗前后心功能指标、血管内皮功能、不良反应发生情况、治疗总有效率。结果治疗后,两组LVEDD、LVESD均下降,LVEF上升,但观察组LVEDD、LVESD显著较低,LVEF显著较高,差异有统计学意义(t=8.147、7.169、8.145,P<0.05);观察组治疗后的vWF、ET水平均较对照组低,NO较对照组高,差异有统计学意义(t=6.166、5.356、5.282,P<0.05);观察组不良反应总发生率为7.14%,较对照组的23.80%低,差异有统计学意义(χ^(2)=4.459,P<0.05);观察组治疗总有效率为92.85%,较对照组的71.43%高,差异有统计学意义(χ^(2)=6.574,P<0.05)。结论以替罗非班联合经皮冠脉介入术对急性心梗患者进行治疗,能够增强其心脏功能,改善其血管内皮功能,降低不良反应发生风险,提高治疗总有效率。
Objective To explore the optimization effect of tirofiban combined with percutaneous coronary intervention in the clinical treatment of patients with acute myocardial infarction.Methods 84 patients with acute myocardial infarction admitted to the hospital from March 2020 to April 2021 were selected as the research objects,and according to the time of admission:they were divided into the control group and the observation group.There were 42 patients in each group,and their admission time was from March to September 2020,and from October 2020 to April 2021.The control group was treated with percutaneous coronary intervention,and the observation group was treated with tirofiban on the basis of the control group.Comparison of cardiac function indexes,vascular endothelial function,occurrence of adverse reaction and total effective rate of treatment between the two groups before and after treatment.Results After treatment,the LVEDD and LVESD of the two groups decreased,and the LVEF increased,but the LVEDD and LVESD of the observation group were significantly lower,and the LVEF was significantly higher,and the difference was statistically significant(t=8.147,7.169,8.145,P<0.05).The levels of vWF and ET were lower than those in the control group,and NO was higher than those in the control group,and the difference was statistically significant(t=6.166,5.356,5.282,P<0.05).The total incidence of adverse reaction in the observation group was 7.14%,which was lower than that in the control group 23.80%,and the difference was statistically significant(χ^(2)=4.459,P<0.05).The total effective rate of the observation group was 92.85%,which was higher than that of the control group 71.43%,and the difference was statistically significant(χ^(2)=6.574,P<0.05).Conclusion Tirofiban combined with percutaneous coronary intervention in the treatment of patients with acute myocardial infarction can enhance their cardiac function,improve their vascular endothelial function,reduce the occurrence risk of adverse reaction,and improve the total effective rate of treatment.
作者
陈小琼
张小双
CHEN Xiaoqiong;ZHANG Xiaoshuang(Department of Cardiovascular Medicine,the First People's Hospital of Guangshui City,Guangshui,Hubei Province,432700 China;Emergency Department,the First People's Hospital of Guangshui City,Guangshui,Hubei Province,432700 China)
出处
《系统医学》
2022年第4期111-114,共4页
Systems Medicine
关键词
替罗非班
经皮冠脉介入术
急性心梗
心功能指标
治疗总有效率
Tirofiban
Percutaneous coronary intervention
Acute myocardial infarction
Cardiac function index
Total effective rate of treatment
