摘要
目的探究糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)患者血清维生素D(25羟维生素D)与抑郁的相关性。方法选取2020年1—10月该院收治的96例DPN患者,入院后均以抑郁自评量表(SDS)进行抑郁筛查,根据筛查结果分为抑郁组(n=69)、非抑郁组(n=27)。所有患者均于入院24 h内检测血清维生素D[25(OH)D]水平,比较两组患者25(OH)D水平差异、维生素D缺乏率,并以Pearson相关分析法探究DPN患者血清25(OH)D水平与抑郁之间的相关性。结果抑郁组患者25(OH)D水平(37.25±9.61)nmol/L,与非抑郁组(46.24±10.12)nmol/L比较明显较低,差异有统计学意义(P<0.001);抑郁组患者维生素D缺乏发生率(77.78%)与非抑郁组(47.83%)比较明显较高,差异有统计学意义(P<0.05);Pearson相关分析显示,25(OH)D水平与SDS评分呈负相关关系(r=-0.457,P<0.001)。结论DPN患者普遍存在血清维生素D缺乏,且维生素D与抑郁密切相关,维生素D缺乏越严重,抑郁发生率越高。
Objective To explore the correlation between serum vitamin D(25-hydroxyvitamin D)and depression in patients with diabetic peripheral neuropathy(DPN).Methods A total of 96 DPN patients admitted to the hospital from January to October 2020 were selected.After admission,self-rating depression scale(SDS)was used for depression screening.According to the screening results,they were divided into depression group(n=69)and non-depression group(n=27).Serum vitamin D[25(OH)D]levels were detected in all patients within 24 h of admission.The differences in 25(OH)D levels and vitamin D deficiency rates were compared between the two groups,and the correlation between serum 25(OH)D levels and depression in DPN patients was explored by Pearson correlation analysis.Results The level of 25(OH)D in the depression group(37.25±9.61)nmol/L was significantly lower than that in the non-depressed group(46.24±10.12)nmol/L,the difference was statistically significant(P<0.001).The incidence of vitamin D deficiency in the depression group(77.78%)was significantly higher than that in the non-depression group(47.83%),the difference was statistically significant(P<0.05).Pearson correlation analysis showed that 25(OH)D level was negatively correlated with SDS score,the correlation coefficient(r=-0.457,P<0.001).Conclusion Serum vitamin D deficiency is common in DPN patients,and vitamin D is closely related to depression.The more severe the vitamin D deficiency,the higher the incidence of depression.
作者
胡颖
HU Ying(Department of Endocrinology,Ordos Central Hospital,Inner Mongolia,Ordos,Inner Mongolia Autonomous Region,017000 China)
出处
《糖尿病新世界》
2022年第5期172-175,共4页
Diabetes New World Magazine
