摘要
目的探讨杂合式血液净化治疗重症有机磷农药中毒的疗效及对患者血清炎性因子的影响。方法方便选取2018年1月—2021年1月该院收治的106例重症有机磷农药中毒患者为研究对象,按照随机数表法分为对照组(n=53)和观察组(n=53)。对照组给予血液灌流治疗,观察组给予杂合式血液净化治疗。比较两组患者恢复指标、脏器受损情况、血清炎性因子以及并发症发生情况。结果观察组患者昏迷时间(5.01±1.32)d、机械通气时间(4.02±1.33)d、胆碱酯酶恢复时间(5.77±1.82)d、总住院时间(9.67±2.54)d均短于对照组(5.89±1.74)、(4.87±1.41)、(7.84±2.08)、(11.59±2.89)d,差异有统计学意义(t=2.933、3.193、5.453、3.633,P<0.05)。治疗24、72 h,观察组患者AST、cTnⅠ、Scr水平低于对照组,差异有统计学意义(P<0.05)。治疗24、72 h,观察组患者IL-6、IL-8、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。观察组并发症总发生率低于对照组(18.9%vs 41.5%),差异有统计学意义(χ^(2)=6.446,P<0.05)。结论杂合式血液净化有助于促进有机磷农药中毒患者恢复,减轻机体脏器功能损伤及炎症反应,降低并发症的发生。
Objective To explore the effect of hybrid blood purification in the treatment of severe organophosphorus pesticide poisoning and its influence on patients'serum inflammatory factors.Methods The 106 patients with severe organophosphorus pesticide poisoning admitted to the hospital from January 2018 to January 2021 were conveniently selected as the research objects,and they were divided into the control group(n=53)and the observation group(n=53)according to the random number table method.The control group was given hemoperfusion therapy,and the observation group was given heterozygous blood purification therapy.The recovery indicators,organ damage,serum inflammatory factors and complications were compared between the two groups.Results The coma time and mechanical ventilation time of observation group were(5.01±1.32)d and(4.02±1.33)d,cholinesterase recovery time(5.77±1.82)d,total hospital stay(9.67±2.54)d were shorter than those of control group(5.89±1.74)d,(4.87±1.41)d,(7.84±2.08)d,(11.59±2.89)d,the difference was statistically significant(t=2.933,3.193,5.453,3.633,P<0.05).After 24 h and 72 h of treatment,the levels of AST,cTnⅠ,and Scr in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After 24 h and 72 h of treatment,the levels of IL-6,IL-8 and TNF-αin the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total incidence of complications in the observation group was lower than that in the control group(18.9%vs 41.5%),and the difference was statistically significant(χ^(2)=6.446,P<0.05).Conclusion Hybrid blood purification helps to promote the recovery of patients with organophosphorus pesticide poisoning,reduce body organ damage and inflammation,and reduce the occurrence of complications.
作者
陈健辉
杜文超
苏君
CHEN Jianhui;DU Wenchao;SU Jun(Emergency Department of Longyan First Hospital Affiliated to Fujian Medical University,Longyan,Fujian Province,364000 China)
出处
《中外医疗》
2022年第4期29-32,共4页
China & Foreign Medical Treatment
关键词
杂合式血液净化
有机磷农药中毒
炎性因子
并发症
血液灌流
Hybrid blood purification
Organophosphorus pesticide poisoning
Inflammatory factors
Complication
Hemoperfusion
