摘要
目的评估多囊卵巢综合征合并2型糖尿病患者采用雌、孕激素联合周期疗法和二甲双胍治疗的效果。方法选择该院在2018年5月—2021年5月接诊的60例多囊卵巢综合征合并2型糖尿病患者,按照随机数表法进行分组,各30例,两组均接受雌、孕激素联合周期疗法,同时,对照组接受阿卡波糖片治疗,观察组接受二甲双胍治疗,对比两组疗效。结果观察组的血清睾酮、黄体生成素、黄体生成素/卵泡刺激素、雌二醇均低于对照组,差异有统计学意义(P<0.05)。观察组空腹胰岛素、空腹血糖、胰岛素抵抗指数均低于对照组,差异有统计学意义(P<0.05)。观察组排卵率、妊娠率均高于对照组,差异有统计学意义(P<0.05)。两组并发症对比,差异无统计学意义(P>0.05)。结论多囊卵巢综合征合并2型糖尿病患者采用雌、孕激素联合周期疗法和二甲双胍治疗的效果准确,值得在临床推广使用。
Objective To evaluate the effect of estrogen and progesterone combined cycle therapy and metformin in patients with polycystic ovary syndrome and type 2 diabetes mellitus.Methods A total of 60 patients with polycystic ovary syndrome and type 2 diabetes admitted to the hospital from May 2018 to May 2021 were selected,and grouped according to the random number table method,with 30 cases in each group.Both groups received estrogen and progesterone combined cycle therapy.At the same time,the control group received acarbose tablet therapy,and the observation group received metformin therapy.The therapeutic effects of the two groups were compared.Results Serum testosterone,luteinizing hormone,luteinizing hormone/follicle-stimulating hormone and estradiol in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).The fasting insulin,fasting blood glucose and insulin resistance index of the observation group were lower than those of the control group,the difference was statistically significant(P<0.05).The ovulation rate and pregnancy rate in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in complications between the two groups(P>0.05).Conclusion The treatment effect of estrogen and progesterone combined cycle therapy and metformin in patients with polycystic ovary syndrome and type 2 diabetes is accurate,and it is worthy of promotion and use in clinical practice.
作者
王丽静
WANG Lijing(Department of Obstetrics and Gynecology,Tengzhou Finance and Trade Hospital,Tengzhou,Shandong Province,277599 China)
出处
《糖尿病新世界》
2022年第4期65-68,共4页
Diabetes New World Magazine
关键词
多囊卵巢综合征
2型糖尿病
雌、孕激素
周期疗法
二甲双胍
Polycystic ovary syndrome
Type 2 diabetes mellitus
Estrogen and progesterone
Cycle therapy
Metformin
