摘要
目的:探究胎儿纤维连接蛋白(fFN)、核转录因子(NF-κB)、高迁移率族蛋白B1(HMGB1)与神经发育关系及预测早产价值。方法:回顾性收集2019年1月-2020年4月本院收治的有早产危险因素孕妇195例临床资料,根据妊娠结局分为早产组(n=51)和足月分娩组(n=144)。检测两组阴道分泌物中fFN及血清NF-κB、HMGB1水平,绘制受试者工作曲线(ROC)分析各指标预测早产价值,比较早产组新生儿神经发育与血清NF-κB、HMGB1表达相关性。结果:出现先兆早产症状3 d内、7 d内、14 d内早产组fFN及血清NF-κB、HMGB1水平均高于足月分娩组(P<0.05);以出现先兆早产症状14 d内fFN及血清NF-κB、HMGB1预测早产价值较高,对应预测敏感度为80.4%,特异度为87.5%;娩出后、生后第3 d、第7 d早产组神经发育不良患儿血清NF-κB、HMGB1水平高于神经发育良好新生儿(P<0.05);新生儿神经发育与其血清NF-κB、HMGB1水平呈正相关(P<0.05)。结论:fFN联合NF-κB、HMGB1检测对早产有较高预测价值,且新生儿血清NF-κB、HMGB1水平与其神经发育关系密切,临床可对早产儿检测上述血清因子以评价神经发育情况,进行早期干预治疗。
Objective: To explore the value of the combination of fetal fibronectin(fFN), nuclear transcription factor(NF-κB), and high mobility group protein B1(HMGB1) for predicting premature delivery, and to study their relevant with neurodevelopment of newborns. Methods: The clinical data of 195 pregnant women with preterm birth risk factors from January 2019 to April 2020 were collected retrospectively. According to the pregnancy outcomes, these women were divided into group A(51 women with preterm birth) and group B(144 women with term birth).The levels of fFN in vaginal secretions and NF-κB and HMGB1 in serum of the women in the two groups were detected. Receiver operating curve(ROC) was drawn to analyze the predictive value of the levels of fFN in vaginal secretions and NF-κB and HMGB1 in serum for preterm birth. The correlation between neural development of preterm newborns and the expression levels of maternal serum NF-κB and HMGB1 was analyzed. Results: The fFN level in vaginal secretions and the level s of serum NF-κB and HMGB1 of the women in group A within 3, 7 and 14 days after the onset of premature delivery were significant higher than those of the women in group B(P<0.05).Within 14 days after the onset of premature delivery, the levels of fFN and serum NF-κB and HMGB1 of the women for predicting preterm labor had higher value, with the sensitivity of 80.4% and the specificity of 87.5%. The levels of serum NF-κB and HMGB1 of the newborns with neurodevelopmental dysplasia on the 3 rd and the 7 th day after born were significant higher than those of the newborns without neurodevelopmental dysplasia(P<0.05).There was a positive correlation between neurodevelopment of the newborns and their serum NF-κB and HMGB1 levels(P<0.05). Conclusion: The combined detections of fFN, NF-κB, and HMGB1 levels has high predictive value for premature delivery, and the levels of serum NF-κB and HMGB1 are closely related to the neonatal neurodevelopment.The levels of serum NF-κB and HMGB1 of the premature infants should be detected for evaluating their neurodevelopment and early intervention treatment in clinic.
作者
牟莹莹
侯玉娇
王伟
MU Yingying;HOU Yujiao;WANG Wei(Weifang Maternal and Child Health Care Hospital,Shandong Province,261011)
出处
《中国计划生育学杂志》
2022年第2期478-482,共5页
Chinese Journal of Family Planning
基金
潍坊市科技发展计划项目(2019YX033)。
关键词
新生儿神经发育
早产
胎儿纤维连接蛋白
核转录因子
高迁移率族蛋白B1
预测
Neurodevelopment
Premature delivery
Fetus fibronectin
Nuclear transcription factor
High mobility group protein B1
Prediction
