摘要
目的:研究血清葡萄糖转运蛋白4(GLUT4)、补体C1q/肿瘤坏死因子相关蛋白3(CTRP3)与多卵巢综合征(PCOS)合并胰岛素抵抗(IR)相关性。方法:将2017年6月-2020年6月本院不孕不育诊疗中心接诊的PCOS患者190例纳为研究对象,根据是否合并胰岛素抵抗(IR)分为IR组(51.6%)与非IR组(48.4%),比较两组血清GLUT4及CTRP3水平并与患者体重指数(BMI)、腰臀比(WHR)血、清胰岛素水平(FINS)、空腹血糖(FPG)、HOMA-IR、血脂代谢等行相关性分析。结果:IR组体质指数(BMI)、腰围及腰臀比(WHR)均高于非IR组,胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)及糖化血红蛋白(HbA1c)水平高于非IR组,高密度脂蛋白(HDL-C)水平低于非IR组,总胆固醇(TC)及甘油三酯(TG)水平高于非R组,血清GLUH4(2.26±0.51pg/ml)及CTRP3(311.51±63.69ng/ml)水平均低于非IR组(4.17±0.73pg/ml、373.63±75.65ng/ml)(均P<0.05)。相关性分析提示,PCOS患者血清GLUH4水平与WHR、FINS及HOMA-IR呈负相关,血清CTRP3与BMI、WHR、HOMA-IR、HbA1c及TG呈负相关,与HDLC水平呈正相关(均P<0.05)。多元线性逐步回归分析,WHR及HOMA-IR是影响血清GLUH4水平的显著因素,HOMA-IR、TG是影响CTRP3水平的显著因素。结论:PCOS患者合并IR占比较高,血清GLUT4蛋白及CTRP3水平低于非IR者。PCOS患者血清GLUT4蛋白水平与患者WHR及HOMA-IR密切相关,GLUT4可能参与了患者腹型肥胖及胰岛素抵抗发病进展;而血清CTRP3与HOMA-IR、TG密切相关,提示CTRP3可能参与了PCOS胰岛素抵抗及脂代谢紊乱。
Objective:To investigate the relationship between serum glucose transporter 4(GLUT4)and complement C1q/tumor necrosis factor-related protein-3(CTRP3)of women and their polycystic ovary syndrome(PCOS)and insulin resistance(IR).Methods:190women with PCOS were enrolled in this study and were divided into group A(51.6%women with IR)and group B(48.4%women without IR)according to the occurrence of IR from June 2017to June 2020.The levels of serum GLUT4and CTRP3of the women were compared between the two groups.The relationship between the levels of serum GLUT4and CTRP3of the women and their levels of fasting insulin(FINS)and fasting plasm glucose(FPG),and their values of body mass index(BMI),waist-to-hip ratio(WHR),HOMA-IR,and blood lipid metabolism indexes was analyzed.Results:The values of BMI and WHR,and the levels of FINS,HOMA-IR,HbA1ctotal cholesterol(TC),and triglyceride(TG)of the women in group A were significantly higher than those of the women in group B,and the high-density lipoprotein(HDL-C)level of the women in group A was significantly lower.The serum levels of GLUH4(2.26±0.51pg/ml)and CTRP3(311.51±63.69ng/ml)of the women in group A were significantly lower than those(4.17±0.73pg/ml and 373.63±75.65ng/ml)of the women in group B(all P<0.05).Correlation analysis showed that serum GLUH4level of the women with PCOS was negatively correlated with their WHR and HOMA-IR values,and their FINS level.The serum CTRP3level of the women with PCOS was negatively correlated with their BMI,WHR,and HOMA-IR values,and the levels of HbA1cand TG,but which was positively correlated with their HDL-C level(all P<0.05).Multiple linear stepwise regression analysis showed that the WHR and HOMA-IR values of the women with PCOS were the significant factors affecting their serum GLUH4level,while the HOMA-IR value and the TG level of the women with PCOS were the significant factors affecting their CTRP3level.Conclusion:In the women with PCOS,the proportion of IR was higher,and the levels of GLUT4and CTRP3of the women with IR are lower than those of the women without IR.The serum GLUT4level of the women with PCOS is closely related to their WHR and HOMA-IR values,and GLUT4may be involves in the progression of abdominal obesity and IR of the women.The serum CTRP3level of the women with PCOS was closely correlated with their HOMA-IR value and their TG level,which suggests that CTRP3may be involved in the IR and lipid metabolism disorder of the women with PCOS.
作者
万彬
陈静
童华诚
WAN Bin;CHEN Jing;TONG Huacheng(Nanjing Tongren Hospital Affiliated to Medical College of Southeast University,Nanjing,Jiangsu Province,211100)
出处
《中国计划生育学杂志》
2022年第4期860-864,共5页
Chinese Journal of Family Planning
