摘要
目的:探讨分化型甲状腺癌(DTC)患者术后放射性131碘(^(131)I)的清甲疗效及影响因素。方法:选取2019年1月至2020年3月在本院就诊的甲状腺癌患者86例,并根据清甲治疗效果分为清甲成功组与清甲不成功组,采用单因素统计分析两组患者的性别、年龄、病理类型、体质指数、^(131)I首次治疗前TSH水平和sTg水平、原发风险分层、原发病灶直径、TNM分期、转移情况、^(131)I首次治疗剂量的差异,采用多因素Logistic回归分析DTC患者^(131)I清甲疗效的影响因素。结果:86例DTC患者中,有52例清甲成功,清甲成功率为60.47%。单因素分析显示,清甲成功组和不成功组在^(131)I首次治疗前sTg水平、复发风险分层、原发病灶直径、^(131)I首次治疗剂量比较,差异有统计学意义(P<0.05);而在性别、年龄、病理类型、体质指数、^(131)I首次治疗前TSH水平、TNM分期、淋巴结转移情况比较,差异无统计学意义(P>0.05)。多因素Logstic回归分析显示,^(131)I首次治疗前sTg水平、原发病灶直径、^(131)I首次治疗剂量是DTC患者^(131)I清甲疗效的独立影响因素(P<0.05)。结论:86例DTC患者清甲成功率为60.47%,^(131)I首次治疗前sTg水平、原发病灶直径、^(131)I首次治疗剂量是术后^(131)I治疗清甲疗效的独立影响因素。
Objective:To explore thyroid ablation efficacy and influencing factors of postoperative radioactive 131 iodine(^(131)I)in patients with differentiated thyroid carcinoma(DTC).Methods:86 patients with thyroid cancer treated in our hospital from January 2019 to March 2020 were selected and divided into successful and unsuccessful ablation efficacy groups according to the effect of ablation efficacy.The differences of gender,age,pathological type,body mass index,TSH level and STG level before ^(131)I first treatment,primary risk stratification,primary lesion diameter,TNM stage,metastasis and ^(131)I first treatment dose between the two groups were analyzed by single factor statistics,Multivariate logistic regression was used to analyze the influencing factors of ^(131)I nail cleaning efficacy in patients with DTC.Results:Among the 86 patients with DTC,52 cases had successful ablation efficacy,and the successful rate was 60.47%.Univariate analysis showed that there were significant differences in STG level,recurrence risk stratification,primary lesion diameter and ^(131)I first treatment dose between the successful group and the unsuccessful group(P<0.05);There was no significant difference in gender,age,pathological type,body mass index,TSH level,TNM stage and lymph node metastasis before ^(131)I treatment(P>0.05).Multivariate logistic regression analysis showed that the level of STG before the first treatment of ^(131)I,the diameter of primary lesion and the first treatment dose of ^(131)I were the independent influencing factors of ^(131)I ablation efficacy in patients with DTC(P<0.05).Conclusion:The success rate of thyroid ablation is 60.47%in the 86 patients with DTC.The sTg level before the first ^(131)I treatment,diameter of primary lesions and dosage of the first ^(131)I treatment are independent influencing factors of thyroid ablation efficacy of ^(131)I on DTC patients.
作者
贾云翔
何兴明
卢万军
赵艳红
赵明杰
JIA Yunxiang;HE Xingming;LU Wanjun(Guangyuan Central Hospital, Sichuan Guangyuan 628000, China)
出处
《河北医学》
CAS
2022年第5期818-822,共5页
Hebei Medicine
基金
四川省卫生健康委员会科研课题,(编号:19PJ079)。
关键词
分化型甲状腺癌
放射性131碘
清甲疗效
影响因素
Differentiated thyroid carcinoma
Radioactive 131 iodine
Thyroid ablation efficacy
Influencing factor
