摘要
目的探讨吗替麦考酚酯联合泼尼松治疗狼疮性肾炎患者的临床疗效及安全性。方法选取2018年9月至2019年4月本院收治的83例狼疮性肾炎患者作为研究对象,采用奇偶数法分为A组(n=42)和B组(n=41)。A组给予泼尼松治疗,B组在A组基础上联合吗替麦考酚酯治疗,比较两组疾病活动度评分、免疫球蛋白水平[免疫球蛋白A(IgA)、免疫球蛋白(IgM)、免疫球蛋白G(IgG)]及不良反应发生情况。结果治疗3、6个月后,两组疾病活动度评分均低于治疗前,且B组低于A组,差异有统计学意义(P<0.05)。治疗6个月后,两组IgA、IgM、IgG水平均低于治疗前,且B组低于A组,差异有统计学意义(P<0.05)。B组不良反应发生率略高于A组,但组间比较差异无统计学意义。结论吗替麦考酚酯联合泼尼松治疗狼疮性肾炎效果显著,可有效降低患者疾病活动度,改善免疫球蛋白水平,安全性较高,值得临床推广应用。
Objective To investigate the clinical effect and safety of mycophenolate mofetil combined with prednisone in the treatment of patients with lupus nephritis.Methods A total of 83 patients with lupus nephritis who admitted to our hospital from September 2018 to April 2019were selected as the study subjects,and they were divided into group A(n=42)and group B(n=41)according to the odd-even method.Group A was treated with prednisone,and group B was treated with mycophenolate mofetil on the basis of group A,the disease activity score,the levels of immunoglobulin(immunoglobulin A[IgA],immunoglobulin M[IgM],immunoglobulin G[IgG])and adverse reactions were compared between the two groups.Results After 3 and 6 months of treatment,the disease activity scores of the two groups were lower than those before treatment,and the group B was lower than the group A,and the difference was statistically significant(P<0.05).After 6 months of treatment,the levels of IgA,IgM,IgG in the two groups were lower than those before treatment,and the group B were lower than those in the group A,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in group B was slightly higher than that in group A,but there was no significant difference between the two groups.Conclusion Mycophenolate mofetil combined with prednisone in the treatment of patients with lupus nephritis can effectively reduce the disease activity,improve the level of immunoglobulin,and has high safety,which is worthy of clinical application.
作者
刘丹
殷强
LIU Dan;YIN Qiang(Department of Pharmacy,Dalian Friendship Hospital,Dalian,Liaoning,116001,China)
出处
《当代医学》
2022年第14期75-77,共3页
Contemporary Medicine
