摘要
目的探讨孟鲁司特钠联合布地奈德福莫特罗粉治疗咳嗽变异性哮喘的临床效果。方法选择2020年7月至2021年6月黑龙江省佳木斯市中心医院诊断治疗的咳嗽变异性哮喘患者60例进行回顾性分析,分为观察组与对照组各30例。观察组治疗采用孟鲁司特钠联合布地奈德福莫特罗,对照组治疗采用布地奈德福莫特罗。比较两组治疗1周、1个月咳嗽频率、程度评分,肺功能指标。结果①治疗1个月后两组的咳嗽频率评分与咳嗽程度评分均呈下降趋势,与治疗前比较,差异有统计学意义(P<0.05);治疗1周、治疗1个月,观察组咳嗽频率评分及咳嗽程度评分均显著低于对照组,差异有统计学意义(P<0.05)。②治疗1周与治疗1个月,观察组FEV_(1)、PEF、FEV_(1)/FVC均呈显著上升的趋势,与治疗前比较,差异有统计学意义(P<0.05);治疗1个月后,观察组FEV_(1)、PEF、FEV_(1)/FVC均显著高于对照组,差异有统计学意义(P<0.05)。结论孟鲁司特钠联合布地奈德福莫特罗用于咳嗽变异性哮喘的治疗可以有效控制症状,改善肺功能。
Objective To investigate the clinical efficacy of montelukast sodium combined with budesonide and formoterol fumarate powder in the treatment of cough variant asthma.Methods The clinical data of 60 patients with cough variant asthma diagnosed and treated in the Central Hospital of Jiamusi City in Heilongjiang Province from July 2020 to June 2021 were retrospectively analyzed.The 60 patients were divided into 30 cases each in the observation group and the control group according to the treatment methods.The observation group was treated with montelukast sodium combined with budesonide and formoterol fumarate,while the control group was treated with budesonide and formoterol fumarate.The scores in the frequency and the degree of cough,and lung function indexes were compared between the two groups at 1 week and 1 month of treatment.Results①The scores in cough frequency and cough degree in two groups after 1 month of treatment,showing a decreasing tendency,and were significantly different from those before treatment(P<0.05).At 1 week and 1 month of treatment,the scores in cough frequency and cough degree in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).②At 1 week and 1 month of treatment,forced expiratory volume in one second(FEV_(1)),peak expiratory flow(PEF)and FEV_(1)/forced vital capacity(FVC)in the observation group were significantly higher than those before treatment,with statistically significant differences(P<0.05).1 month after treatment,FEV_(1),PEF and FEV_(1)/FVC in the observation group were significantly higher than those in the control group,with statistically significant differences(P<0.05).Conclusion Montelukast sodium combined with budesonide and formoterol fumarate can effectively control symptoms and improve lung function for patients with cough variant asthma.
作者
张琪
ZHANG Qi(Department of Pharmacy,the Central Hospital of Jiamusi City in Heilongjiang Province,Jiamusi 154000,China)
出处
《中国现代医生》
2022年第11期128-130,139,共4页
China Modern Doctor
关键词
孟鲁司特钠
布地奈德福莫特罗
咳嗽变异性哮喘
肺功能
Montelukast sodium
Budesonide and formoterol fumarate
Cough variant asthma
Lung function
