摘要
目的探讨促甲状腺激素(TSH)、抗甲状腺过氧化物酶抗体(TPOAb)、促甲状腺受体抗体(TRAb)及抗甲状腺球蛋白抗体(TG-Ab)对自身免疫性甲状腺疾病进行联合检测诊断的临床价值。方法选取2020年3月至2021年3月到江苏省邳州市中医院接受健康体检的50名人员设为健康组,并选取同一时期该院收治的50例疑似自身免疫性甲状腺疾病患者作为甲状腺组。所有患者均采集5 ml静脉血,在1 h内经过血清分离处理,并用Roche公司生产的全自动电化学发光免疫分析仪(E601型)联合检测TSH、TPOAb、TRAb及TG-Ab,分析比较两组检测结果。结果甲状腺组FT_(3)与健康组比较,差异无统计学意义(P>0.05),而甲状腺组的TT_(3)、TT_(4)和FT_(4)指标水平明显高于健康组,差异有统计学意义(P<0.05);甲状腺组TSH、TPOAb、TRAb及TG-Ab指标水平均明显高于健康组,差异有统计学意义(P<0.001);甲状腺组TSH、TPOAb、TRAb及TG-Ab各项指标阳性检出率均显著高于健康组,差异有统计学意义(P<0.05)。结论采用TSH、TPOAb、TRAb及TG-Ab联合检测法诊断自身免疫性甲状腺疾病,临床价值较为显著,值得在临床上推广应用。
Objective To explore the clinical value of combined detection of thyroid-stimulating hormone(TSH),anti-thyroid peroxidase antibody(TPOAb),thyroid-stimulating receptor antibody(TRAb),and anti-thyroglobulin antibody(TG-Ab)in the diagnosis of autoimmune thyroid diseases.Methods A total of 50 patients who underwent health examination in the Pizhou Hospital of Traditional Chinese Medicine in Jiangsu Province from March 2020 to March 2021 were selected as the healthy group,and 50 patients with suspected autoimmune thyroid disease admitted to the hospital during the same period were selected as the thyroid group.Five milliliters of venous blood were collected from all patients and treated with serum separation within 1 hour.The combined detection of TSH,TPOAb,TRAb,and TG-Ab was performed using Roche′s automatic electrochemiluminescence immunoassay analyzer(model E601).The test results of the two groups were analyzed and compared.Results There was no significant difference in FT_(3)between the thyroid group and the healthy group(P>0.05).The levels of TT_(3),TT_(4),and FT_(4)in the thyroid group were significantly higher than those in the healthy group,and the difference had statistical significance(P<0.05).The levels of TSH,TPOAb,TRAb,and TG-Ab in the thyroid group were significantly higher than those in the healthy group,and the difference had statistical significance(P<0.05).The positive detection rates of TSH,TPOAb,TRAb and TG-Ab in the thyroid group were significantly higher than those in the healthy group.The difference had statistical significance(P<0.05).Conclusion The combined detection of TSH,TPOAb,TRAb,and TG-Ab has a significant clinical diagnostic value for autoimmune thyroid diseases,which is worthy of clinical promotion and application.
作者
王红艳
WANG Hongyan(Department of Clinical Laboratory,Pizhou Hospital of Traditional Chinese Medicine in Jiangsu Province,Pizhou 221300,China)
出处
《中国现代医生》
2022年第12期141-143,178,共4页
China Modern Doctor
