摘要
Background:Inflammation is often related to cancer,and several inflammatory scores have been established to predict the prognosis of various types of cancer.Our study aimed to determine the prognostic value of the preoperative lymphocyte to C-reactive protein ratio(LCR)for predicting postoperative outcomes in patients with resectable gallbladder cancer(GBC).Methods:A retrospective analysis of 104 GBC patients who received curative surgery at Xinhua Hospital,Affiliated to Shanghai Jiao Tong University School of Medicine from January 2000 to December 2016 was performed.A time-dependent receiver operating characteristic curve was constructed to evaluate the accuracy of different markers.Univariate and multivariate Cox proportional hazard models were used to define factors associated with overall survival.Results:Among the assessed variables,the preoperative LCR showed the highest accuracy in predicting the overall survival of GBC patients(AUC:0.736).Decreased preoperative LCR was significantly associated with advanced tumor stage,including tumor invasion(P=0.018),lymph node metastasis(P=0.011)and TNM stage(P=0.022).A low preoperative LCR(cutoff threshold=145.5)was an independent risk factor for overall survival in patients with resectable GBC(P<0.001).Conclusions:The preoperative LCR is a novel and valuable prognostic indicator of postoperative survival in patients with resectable GBC.
基金
supported by grants from the National Natural Science Foundation of China(81974371)
the Emerging Frontier Program of Hospital Development Center(SHDC12018107)
the General Surgery Construction Program of Shanghai Municipal Health Commission(2017ZZ02011)
the Project of Excellent Young Scholars from Shanghai Municipal Health and Family Planning Commission(2018YQ10)
the Talent Development Fund from Shanghai Municipal Human Resources and Social Security Bureau(2018048)
the Experiment Animal Program of Shanghai Science and Technology Committee Innovative(19140902700)
Research Team of High-level Local Universities in Shanghai
Shanghai Key Laboratory of Biliary Tract Disease Research Foundation(17DZ2260200)
the National Science and Technology Major Project(2019ZX09301-158)。
