摘要
目的系统评价肺癌患者术后静脉血栓栓塞发生的情况和特点,为开展肺癌患者术后相关预防与控制工作提供科学依据。方法计算机检索中国知网、维普、中国生物医学文献数据库、万方、PubMed、Embase和Web of Science数据库,搜集关于中国肺癌患者术后静脉血栓发生率的横断面研究,检索时限均从建库至2021年10月。采用Stata 15.1软件进行Meta分析。结果最终纳入11篇文献,共计2862例肺癌术后患者,其中326例患者发生肺静脉血栓栓塞。Meta分析结果显示,肺癌术后静脉血栓栓塞发生率为16.0%(95%CI:0.12~0.20)。亚组分析显示中国肺癌术后静脉血栓栓塞发生率在有/无吸烟史(20%/10%)、有/无高血压史(23%/10%)、有/无冠心病史(21%/11%)、有/无糖尿病史(19%/13%)、老年/中青年(24%/14%)中差异有统计学意义(P<0.01)。结论中国肺癌术后患者静脉血栓栓塞发生率较高,有吸烟史、高血压史、冠心病史、糖尿病史肺癌术后静脉血栓栓塞发生率更高。
Objective To systematically evaluate the occurrence and characteristics of postoperative venous thromboembolism(VTE)in patients with lung cancer,and to provide a scientific basis for the relevant postoperative prevention and control of lung cancer patients.Methods The CNKI,VIP,SinoMed,WanFang,PubMed,Embase,and Web of Science databases were searched for cross-sectional studies on the incidence of postoperative VTE in Chinese lung cancer patients,and the retrieval time limit ranged from library establishment to October 2021.Meta-analysis was conducted by Stata 15.1 software.Results Finally,11 articles were included,involving a total of 2862 patients with lung cancer after surgery,of which 326 patients developed pulmonary VTE.The results of the Meta-analysis showed that the postoperative VTE incidence of lung cancer was 16.0%(95%CI:0.12-0.20).Subgroup analysis showed that the incidence of VTE after lung cancer surgery in China was significantly different in patients with/without smoking history(20%/10%),with/without history of hypertension(23%/10%),with/without history of coronary heart disease(21%/11%),with/without diabetes history(19%/13%),elderly/young and middle-aged(24%/14%)(P<0.01).Conclusion The incidence of VTE in Chinese patients after lung cancer surgery is higher,and the incidence of VTE after lung cancer surgery is higher with a history of smoking,hypertension,coronary heart disease,and diabetes.
作者
李莉
周培华
薛翔
伏加慧
LI Li;ZHOU Pei-hua;XUE Xiang;FU Jia-hui(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital with Nanjing Medical University,Jiangsu Province Hospital,Nanjing,Jiangsu 210029,China)
出处
《中国临床研究》
CAS
2022年第5期627-631,共5页
Chinese Journal of Clinical Research
基金
国家重点研发计划专项(2018YFC1311900)。
关键词
肺癌
静脉血栓栓塞
冠心病
糖尿病
高血压
吸烟
Lung cancer
Venous thromboembolism
Coronary heart disease
Diabetes
Hypertension
Smoking
