摘要
目的:分析美沙拉嗪联合枯草杆菌二联活菌肠溶胶囊治疗轻、中度溃疡性结肠炎患者的效果。方法:选取2019年1月至2019年12月在郑州大学附属郑州中心医院就诊的轻、中度溃疡性结肠炎患者88例为研究对象,以随机分组法分为对照组与观察组,各44例。美沙拉嗪肠溶片单药治疗方案应用于对照组,观察组采用美沙拉嗪联合枯草杆菌二联活菌肠溶胶囊治疗,比较两组患者的炎症改善情况和生存质量、治疗效果、不良反应。结果:治疗后两组患者的白细胞介素–8(IL–8)、肿瘤坏因子–α(TNF–α)、C反应蛋白(CRP)均有不同程度下降,且观察组的IL–8、TNF–α、CRP低于对照组,差异具有统计学意义(P<0.05)。治疗后观察组生存质量特异性量表(DSQL)评分、不良反应低于对照组,总有效率高于对照组,差异均具有统计学意义(P<0.05)。两组患者的疼痛评分较治疗前下降,生活质量评分提高,且观察组的疼痛评分低于对照组,生活质量评分高于对照组,差异具有统计学意义(P<0.05)。结论:美沙拉嗪联合枯草杆菌二联活菌肠溶胶囊治疗轻、中度溃疡性结肠炎患者,可有效缓解炎症,提高患者的生活质量。
Objective To analyze the effect of mesalazine combined with bacillus subtilis viable enteric capsules in the treatment of patients with mild and moderate ulcerative colitis.Methods A total of 88 patients with mild and moderate ulcerative colitis treated in Zhengzhou Central Hospital Affiliated to Zhengzhou University from January to December 2019 were selected as the research objects,and they were randomly divided into control group and observation group,with 44 cases in each group.The single-drug regimen of mesalazine enteric-coated tablets was applied to the control group,and the observation group was treated with mesalazine combined with bacillus subtilis viable enteric capsules.The improvement of inflammation,quality of life,treatment effect,and adverse reactions between the two groups were compared.Results After treatment,the levels of interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) in the two groups were decreased to varying degrees,and the levels of IL-8,TNF-α and CRP in the observation group were lower than those in the control group,with statistically significant differences(P < 0.05).After treatment,the diabetes specific quality of life scale (DSQL) scores and adverse reactions of the observation group were lower than those of the control group,and the total effective rate of the observation group was higher than that of the control group,with statistically significant differences (P < 0.05).After treatment,the scores of pain and quality of life in the observation group were better than those in the control group,with statistically significant differences (P < 0.05).Conclusion Mesalazine combined with bacillus subtilis enteric-coated capsules can effectively relieve inflammation and improve the quality of life of patients with mild and moderate ulcerative colitis.
作者
吕鹏
宋少华
范雷
LYU Peng;SONG Shao-hua;FAN Lei(Zhengzhou Central Hospital Affiliated to Zhengzhou University,Henan Zhengzhou 450007;Henan Provincial Center for Disease Control and prevention,Henan Zhengzhou 450007)
出处
《深圳中西医结合杂志》
2022年第5期4-8,共5页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
河南省卫生厅科技攻关项目(201702275)。
