摘要
目的:探讨不同剂量盐酸氨溴索治疗老年人呼吸机相关性肺炎(VAP)的效果。方法:选取2016年6月至2020年6月河池市第三人民医院收治的60例VAP患者,随机分为观察组和对照组,每组30例。对照组给予30 mg盐酸氨溴索,观察组给予300 mg盐酸氨溴索。比较两组患者的临床疗效、细菌清除率、重症监护病房(ICU)住院时间、机械通气时间、炎症指标〔临床肺部感染评分(CPIS)、C反应蛋白(CRP)、降钙素原(PCT)〕及不良反应。结果:观察组患者临床治疗总有效率(93.33 %)显著高于对照组(73.33 %),差异具有统计学意义(P<0.05)。观察组患者细菌清除率为53.33 %,显著高于对照组的26.67 %,差异具有统计学意义(P<0.05)。观察组患者ICU住院时间、机械通气时间较对照组显著更短,差异具有统计学意义(P<0.05)。治疗后,观察组患者CPIS、CRP、PCT水平较对照组显著更低,差异具有统计学意义(P<0.05)。观察组不良反应发生率(16.67 %)与对照组(20.00 %)比较,差异无统计学意义(P>0.05)。结论:大剂量盐酸氨溴索治疗老年VAP患者的疗效优于常规剂量,可有效控制感染,改善临床预后。
Objective To investigate the effect of different doses of ambroxol hydrochloride in the treatment of elderly patients with ventilator-associated pneumonia (VAP).Methods A total of 60 patients with VAP admitted to The Third People’s Hospital of Hechi City from June 2016 to June 2020 were randomly divided into observation group and control group,with 30 patients in each group.The control group was given 30 mg ambroxol hydrochloride and the observation group was given 300 mg ambroxol hydrochloride.The clinical efficacy,bacterial clearance rate,intensive care unit (ICU) stay,mechanical ventilation duration,inflammatory indexes[clinical pulmonary infection score (CPIS),C-reactive protein (CRP),procalcitonin (PCT)]and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 93.33%,significantly higher than 73.33% in the control group,and the difference was statistically significant (P < 0.05).The bacterial clearance rate of the observation group was 53.33%,which was significantly higher than 26.67% of the control group,and the difference was statistically significant (P < 0.05).The length of ICU stay and mechanical ventilation time in the observation group were significantly shorter than those in the control group,with statistical significance (P < 0.05).After treatment,the levels of CPIS,CRP and PCT in the observation group were significantly lower than those in the control group,with statistical significances (P < 0.05).There was no significant difference in the incidence of adverse reactions between the observation group (16.67%) and the control group (20.00%) (P > 0.05).Conclusion The efficacy of high dose ambroxol hydrochloride in the treatment of elderly patients with VAP is better than conventional dose,which can effectively control infection and improve clinical prognosis.
作者
韦玉秀
韦树旺
谢玲玲
黄洪斌
兰婕燕
韦张旭
WEI Yu-xiu;WEI Shu-wang;XIE Ling-ling;HUANG Hong-bin;LAN Jie-yan;WEI Zhang-xu(The Third People's Hospital of Hechi City,Guangxi Hechi 547000)
出处
《深圳中西医结合杂志》
2022年第5期22-25,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
呼吸机相关性肺炎
盐酸氨溴索
老年人
Ventilator-associated pneumonia
Ambroxol hydrochloride
Elderly
