摘要
目的系统评价小檗碱治疗2型糖尿病的效果及安全性。方法检索PubMed、Elsevier、知网、维普、万方数据库,2010-2020年小檗碱对2型糖尿病疗效的临床随机对照试验(RCT)。检索文献后阅读摘要联合NoteExpress软件进行管理、筛选、数据提取,使用Cochrane文献偏倚风险评估文献质量,应用RevMan5.3软件对纳入文献进行统计分析。结果共纳入12个RCT,共计1237例2型糖尿病患者。小檗碱在降低空腹血糖[MD=-1.18,95%CI(-1.58,-0.78),Z=5.79,P<0.05]、餐后2 h血糖[MD=-1.23,95%CI(-1.71,-0.74),Z=4.98,P<0.05]、糖化血红蛋白[MD=-0.74,95%CI(-0.86,-0.61),Z=11.28,P<0.05]、C反应蛋白[MD=-0.64,95%CI(-0.79,-0.50),Z=8.90,P<0.05]、白细胞介素-6[MD=-1.68,95%CI(-2.18,-1.17),Z=6.52,P<0.05]方面均优于对照组;小檗碱治疗2型糖尿病产生的不良反应,两组比较差异无统计学意义(P>0.05),治疗效果安全有效。结论小檗碱治疗2型糖尿病具有良好的疗效,但由于纳入文献质量和研究数量的限制,上述结论仍需进一步开展质量更高、样本量充足的随机对照试验。
Objective To systematically evaluate the efficacy and safety of berberine in the treatment of type 2 diabetes mellitus(T2DM).Methods The databases of PubMed,Elsevier,China National Knowledge Internet,VIP and Wanfang were retrieved for clinical randomized controlled trials(RCTs)on the efficacy of berberine in T2DM from 2010 to 2020.The retrieved works of literature were managed,screened,and extracted for data through roughly reading the abstracts in combination with the application of NoteExpress software.The quality of literature was assessed using Cochrane Literature Risk of Bias,and the included works of literature were statistically analyzed by Review Manager 5.3 software.Results 12 RCTs with a total of 1237 patients with T2DM were included.Berberine was more effective in reducing fasting glucose(MD=-1.18,95%CI[-1.58,-0.78],Z=5.79,P<0.05),2-h postprandial blood glucose(MD=-1.23,95%CI[-1.71,-0.74],Z=4.98,P<0.05),glycated hemoglobin(MD=-0.74,95%CI[-0.86,-0.61],Z=11.28,P<0.05),C-reactive protein(MD=-0.64,95%CI[-0.79,-0.50],Z=8.90,P<0.05),and interleukin-6(MD=-1.68,95%CI[-2.18,-1.17],Z=6.52,P<0.05)for patients with T2DM than for study controls.There was no statistically significant difference between patients with T2DM and study controls in adverse reactions of berberine in the treatment of T2DM(P>0.05),and the treatment was safe and effective.Conclusion Berberine has good efficacy in the treatment of T2DM.However,due to the limitation of the quality of the included works of literature and the number of studies,the above conclusion should be further validated by conducting RCTs highe r quality and sufficient sample size.
作者
韩倩楠
刘瑞连
田学其
阮婷婷
彭静
朱海利
HAN Qiannan;LIU Ruilian;TIAN Xueqi;RUAN Tingting;PENG Jing;ZHU Haili(Hunan University of Chinese Medicine,Hunan,Changsha 410208,China;Hunan Academy of Traditional Chinese Medicine Affiliated Hospital,Hunan,Changsha 410006,China;Changsha Health Vocational College,Hunan,Changsha 410000,China)
出处
《中国医药科学》
2022年第8期32-36,63,共6页
China Medicine And Pharmacy
基金
湖南省教育厅科学研究项目(19A366)
湖南省中医药科研计划项目(2021028)
湖南省护理学一级学科开放基金(2019HLX03)。
关键词
小檗碱
2型糖尿病
疗效
META分析
Berberine
Type 2 diabetes mellitus
Efficacy
Meta-analysis
