摘要
目的运用网状meta分析方法系统评价异甘草酸镁及多烯磷脂酰胆碱等5种保肝药物治疗药物性肝损伤的效果。方法检索中国知网、万方、维普数据库,获得相关的临床随机和半随机对照试验。使用《Cochrane系统评价员手册》对文献进行风险偏倚评估,使用R 4.0.3软件进行网状meta分析。结果共纳入48篇文献,网状meta分析结果显示,总有效率及降低血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)水平的顺序为由高到低为:异甘草酸镁>复方甘草酸苷>还原型谷胱甘肽≈多烯磷脂酰胆碱>甘草酸二铵。结论异甘草酸镁治疗药物性肝损伤的总有效率最高,在降低ALT、AST以及TBIL水平方面的作用强于其他4种药物。
Objective To systematically evaluate the effects of five liver protective drugs including magnesium isoglycyrrhizinate and polyene phosphatidylcholine on drug-induced liver injury(DILI)by network metaanalysis.Methods The databases including CNKI,Wanfang and VIP were searched to retrieve relevant randomized and semi-randomized controlled clinical trials."Cochrane Reviewers'Handbook"was used to evaluate the risk bias of the literature,and R 4.0.3 software was used for the network meta-analysis.Results A total of 48 pieces of literature were included.The results of network meta-analysis showed that the descending order in terms of the total effective rate and reducing the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)was magnesium isoglycyrrhizinate>compound glycyrrhizin>reduced glutathione≈polyene phosphatidylcholine>diammonium glycyrrhizinate.Conclusion Magnesium isoglycyrrhizinate shows the highest total effective rate in the treatment of DILI,and its effect on reducing the levels of ALT,AST and TBIL is stronger than that of the other four drugs.
作者
冷楠楠
刘永军
邱玉
蒋范黎
傅淑涵
韦思达
汪倩
LENG Nannan;LIU Yongjun;QIU Yu;JIANG Fanli;FU Shuhan;WEI Sida;WANG Qian(China Pharmaceutical University,Jiangsu,Nanjing 211198,China)
出处
《中国医药科学》
2022年第8期42-47,106,共7页
China Medicine And Pharmacy
关键词
异甘草酸镁
多烯磷脂酰胆碱
还原型谷胱甘肽
复方甘草酸苷
甘草酸二铵
药物性肝损伤
网状meta分析
Magnesium isoglycyrrhizinate
Polyene phosphatidylcholine
Reduced glutathione
Compound glycyrrhizin
Diammonium glycyrrhizinate
Drug-induced liver in jury
Network meta-analysis
