摘要
目的分析癫狂梦醒汤加减在难治性精神分裂症中的应用效果及对阳性和阴性症状量表(PANSS)评分和认知功能的影响。方法采用随机数字表法将2018年1月—2020年12月江西省赣州市第三人民医院收治的50例难治性精神分裂症患者分为参照组和病例组,其中参照组(25例)给予氯氮平治疗,病例组(25例)在此基础上给予癫狂梦醒汤加减治疗,对比2组患者PANSS评分、认知功能、不良反应发生率。结果2组治疗前阳性症状、阴性症状、一般病理症状、PANSS总分、DS、MOCA评分差异无统计学意义(P>0.05),治疗后评分均改善,且病例组阳性症状、阴性症状、一般病理症状、PANSS总分较参照组更低,DS、MOCA评分更高,差异有统计学意义(P<0.05);2组静坐不能、嗜睡、震颤、视物模糊等不良反应发生率比较,差异无统计学意义(P>0.05)。结论难治性精神分裂症给予癫狂梦醒汤治疗有助于改善临床症状,提高认知能力,且安全性可靠,是值得推广借鉴的治疗方法。
Objective To analyze the effect of Diankuang Mengxing decoction in the treatment of refractory schizophrenia and its influence on the PANSS score and cognitive function.Methods Using random number table method,50 patients with refractory schizophrenia admitted to the Third People’s Hospital of Ganzhou from January 2018 to December 2020 were divided into reference group and case group.The reference group(n=25)was given clozapine for treatment,and the case group(n=25)was given Diankuang Mengxing decoction on this basis.The PANSS score,cognitive function,and incidence of adverse reactions were compared between the two groups.Results There was no significant difference in the positive symptoms,negative symptoms,general pathological symptoms,PANSS total score,DS,and MOCA scores between the two groups before treatment(P>0.05),and the scores improved after treatment,and the positive symptoms,negative symptoms.The general pathological symptoms and total score of PANSS were lower than the reference group,and the scores of DS and MOCA were higher,and the difference was statistically significant(P<0.05).There was no difference in the incidence of adverse reactions such as akathisia,lethargy,tremor,and blurred vision between the two groups Statistical significance(P>0.05).Conclusion The treatment of refractory schizophrenia with Diankuang Mengxing decoction can help improve clinical symptoms and cognitive ability,and is safe and reliable.It is a treatment method worthy of promotion.
作者
刘小军
LIU Xiaojun(Department of Psychiatry,the Third People’s Hospital of Ganzhou,Jiangxi Province,Ganzhou 341000,China)
出处
《中国中医药现代远程教育》
2022年第11期99-101,共3页
Chinese Medicine Modern Distance Education of China
关键词
癫狂
难治性精神分裂症
癫狂梦醒汤
阳性和阴性症状量表
认知功能
中医药疗法
insane
refractory schizophrenia
Diankuang Mengxing decoction
positive and negative symptom scale
cognitive function
therapy of traditional Chinese medicine
