摘要
目的探讨腹腔镜手术对早期宫颈癌患者应激指标、免疫指标及预后的影响。方法根据治疗方式的不同将64例早期宫颈癌患者分为对照组和观察组,每组32例,对照组患者采用传统开腹手术治疗,观察组患者采用腹腔镜手术治疗。比较两组患者的应激指标[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]、免疫指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、并发症发生率及术后复发率、死亡率。结果术后,两组患者的TNF-α、CRP、IL-6水平均高于本组术前,观察组患者的TNF-α、CRP、IL-6水平均低于对照组,差异均有统计学意义(P﹤0.05)。术后,两组患者的CD4^(+)水平及CD4^(+)/CD8^(+)均低于本组术前,CD8^(+)水平均高于本组术前,观察组患者的CD4^(+)水平和CD4^(+)/CD8^(+)均高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者的并发症总发生率为6.25%,低于对照组患者的28.12%,差异有统计学意义(P﹤0.05)。术后2年,观察组患者的复发率低于对照组,差异有统计学意义(P﹤0.05)。结论与传统开腹手术相比,腹腔镜手术治疗早期宫颈癌可减轻患者的应激反应,改善免疫抑制状态,降低术后复发风险,且并发症发生率较低。
Objective To investigate the effect of laparoscopic surgery on stress indicators,immune indexes,and prognosis of early cervical cancer patients.Method A total of 64 patients with early cervical cancer were divided into control group and observation group according to different treatment methods with 32 cases in each group.Patients in the control group were treated with traditional laparotomy,and patients in the observation group were treated with laparoscopic surgery.Stress indicators[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)],immune indexes(CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),the incidence rate of complications,postoperative recurrence rate,and mortality rate were compared between the two groups.Result After the operation,the levels of TNF-α,CRP,and IL-6 in the two groups were higher than those before the operation,and the levels of TNF-α,CRP,and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the operation,the levels of CD4^(+),and CD4^(+)/CD8^(+)in the two groups were lower and the levels of CD8^(+)were higher than those before the operation,the levels of CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and the level of CD8^(+)was lower than that in the control group,and the differences were statistically significant(P<0.05).The total incidence rate of complications in the observation group was 6.25%,which was lower than 28.12%in the control group,and the difference was statistically significant(P<0.05).Two years after the operation,the recurrence rate of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Laparoscopic surgery could reduce the stress response,improve the immunosuppressive state,and reduce the risk of postoperative recurrence with a lower incidence rate of complications compared with traditional laparotomy for patients with early cervical cancer.
作者
朱丹
郝婷
ZHU Dan;HAO Ting(Department of Gynaecology,Shunyi Maternity and Childcare Hospital of Beijing/Shunyi Women’s and Children’s Hospital of Beijing Children’s Hospital,Beijing 101300,China)
出处
《癌症进展》
2022年第8期840-843,共4页
Oncology Progress
关键词
腹腔镜手术
传统开腹手术
宫颈癌
应激指标
免疫指标
laparoscopic surgery
traditional laparotomy
cervical cancer
stress indicator
immune index
