摘要
目的分析甲状腺肿大儿童补服碘油丸前后甲状腺容积的变化,评估碘油丸补碘方式在短期内对儿童甲状腺肿大的复原效果。方法2018年10月,选择临夏回族自治州历史病情相对较重,且8~10岁儿童甲状腺肿大率较高的4个乡镇,对辖内19所乡镇小学的8~10岁儿童进行甲状腺检查,以60名甲状腺肿大儿童为研究对象,并随机选择138名甲状腺B超检查正常的同龄儿童作为同期对照。在正常饮食情况下,对甲状腺肿大儿童进行一次性补服碘油丸200 mg干预,并在6个月后,采用B超法测量甲状腺肿大儿童和同期对照儿童的甲状腺容积。结果最终纳入甲状腺肿大儿童53名,男女性别比为1.00∶1.04(26∶27),同期对照儿童138名,男女性别比为1.00∶1.30(60∶78)。补服碘油丸6个月后,甲状腺肿大儿童甲状腺容积中位数为3.7 ml,与补服碘油丸前(5.8 ml)比较差异有统计学意义(Z=-7.95,P<0.001),与同期对照儿童(4.1 ml)比较差异无统计学意义(Z=-0.91,P=0.365);其中,有90.6%(48/53)的儿童甲状腺容积恢复到正常范围,8、9、10岁年龄组分别有100.0%(15/15)、81.8%(18/22)和93.8%(15/16)的儿童甲状腺容积恢复到正常范围,且以8岁年龄组比例最高。按年龄、性别分层,各年龄组及性别甲状腺肿大儿童在补服碘油丸后甲状腺容积均低于补服碘油丸前(P均<0.001),而与同期对照儿童比较差异均无统计学意义(P均>0.05)。补服碘油丸后,甲状腺肿大儿童甲状腺各径线较补服碘油丸前均明显降低(P均<0.001);且与同期正常儿童比较,甲状腺右宽、左长和右长径线差异均有统计学意义(P均<0.05)。结论补服碘油丸能够在短期内使8~10岁甲状腺肿大儿童的甲状腺容积恢复至正常范围,可有效治疗单纯性甲状腺肿大。
Objective To analyze the changes of thyroid volume before and after supplementation with lipiodol pills in children with goiter,and to evaluate the recovery effect of lipiodol pills supplementation on children with goiter in the short term.Methods In October 2018,4 townships and towns in Linxia Hui Autonomous Prefecture with relatively serious historical conditions and high goiter rate of children aged 8 to 10 were selected for thyroid examination in 19 primary schools within the jurisdiction.Sixty children with goiter were selected as research subjects;at the same time,138 children of the same age with normal thyroid B-ultrasound examination results were selected as control in the same period.Under the condition of normal diet,children with goiter were intervened by taking 200 mg lipiodol pills at one time.After 6 months,the thyroid volume of children with goiter and control children was measured by B-ultrasound.Results Fifty-three children with goiter were finally included,with a sex ratio of 1.00∶1.04(26∶27).There were 138 control children in the same period,with a sex ratio of 1.00∶1.30(60∶78).Six months after taking lipiodol pills,the median thyroid volume of children with goiter was 3.7 ml,which was significantly different from that before supplementing with lipidol pills(5.8 ml,Z=-7.95,P<0.001),and not significantly different from that of control children(4.1 ml)in the same period(Z=-0.91,P=0.365).Among them,90.6%(48/53)of children with goiter recovered to the normal range,and 100.0%(15/15),81.8%(18/22)and 93.8%(15/16)children's thyroid recovered returned to the normal range in the 8-,9-,and 10-year-old age groups,respectively,and the highest proportion was in the 8-year-old age group.Stratified by age and gender,the thyroid volume of children with goiter in all age groups and gender after supplementation with lipiodol pills was lower than that before supplementation with lipiodol pills(P<0.001),but there was no difference compared with the control children in the same period(P>0.05).After supplementing with lipiodol pills,the diameters of thyroid in children with goiter were significantly lower than those before supplementing with lipiodol pills(P<0.001).Compared with the control children in the same period,there were significant differences in the right width,left length and right long diameter of the thyroid(P<0.05).Conclusion Supplementing lipiodol pills can restore the thyroid volume of 8-10 year old children with goiter to normal range in a short term,and can effectively treat simple goiter.
作者
高艳鹏
马荣昌
姜田园
丁维奇
张耀怡
唐致琼
阮烨
Gao Yanpeng;Ma Rongchang;Jiang Tianyuan;Ding Weiqi;Zhang Yaoyi;Tang Zhiqiong;Ruan Ye(Institute of Occupational and Environmental Health,School of Public Health,Lanzhou University,Lanzhou 730000,China;Office for Endemic Disease Prevention and Control of Linxia Hui Autonomous Prefecture,Linxia 731100,China)
出处
《中华地方病学杂志》
CAS
北大核心
2022年第5期384-388,共5页
Chinese Journal of Endemiology
基金
临夏州科技计划项目(2018-Z-2-019)。
