摘要
Successful treatment of neurodegenerative diseases(NDDs),including Alzheimer’s disease(AD),Parkinson’s disease(PD),and Huntington’s disease(HD),remains a significant challenge for neurologists due to the undesirable curative outcomes.Apart from surgeries,most drugs are only used to relieve the patients’symptoms without a permanent cure of the disease.The development of novel biomaterials targeting NDDs is greatly hindered by the limited understanding of underlying molecular mechanisms.Considering the difficulties in NDD drug development and clinical trials,a comprehensive and up-to-date review of disease pathogenesis and related novel therapies are needed.In the current article,the basic concepts and pathogenic characteristics of NDDs are firstly illustrated.Following the detailed description of molecular mechanisms underlying three common NDDs,recent advances of drug development based on targeting different pathogenic mechanisms are clarified.Hopefully,this review will be beneficial to address the gap between materials and targeted mechanisms while simultaneously provide suggestions for the future design of precise NDD medicine.
基金
This work was supported by the National Natural Science Fund of China(No.61961136001)
the Guangdong Basic and Applied Research Foundation(No.2019B1515120043)
Natural Science Foundation of Guangdong Province(No.2020A151501612)
the Science and Technology Project of Shenzhen(No.JCYJ20180508152903208)
The authors also acknowledged the support from the Photonics Center and Instrumental Analysis Center of Shenzhen University.
