摘要
目的运用数据挖掘方法探析张法荣教授治疗慢性肾衰竭的用药规律,为慢性肾衰竭中医治疗提供参考。方法收集山东省中医院2019年6月至2021年6月张法荣教授门诊就诊的160例慢性肾衰竭患者的病历信息,运用Excel、IBM SPSS Modeler 25.0、Cytoscape软件对病历信息进行频数统计、聚类分析和复杂网络分析。结果共纳入334首方剂,涉及药物159种。药物四气频次排名前3位的为平性、温性和寒性药;五味频次排名前3位的为甘味、苦味和辛味药;归经频次排名前3位的为肝、脾和肾经。获得支持度最高的前4组药对:黄芪-党参;山药-芡实;黄芪-党参,杜仲;六月雪-大黄。药物聚类分析挖掘得到两组药物组合。结论张法荣教授治疗慢性肾衰竭以补脾益肾、滋养肝肾、祛瘀泄浊为治疗大法,虚实兼顾,获效甚佳。
Objective To explore Professor Zhang Farong’s medication rule in the treatment of chronic renal failure by using data mining method,and to provide reference for the treatment of traditional Chinese medicine of chronic renal failure.Methods The case information of 160 patients with chronic renal failure treated by Professor Zhang Farong in Shandong Hospital of Traditional Chinese Medicine from June 2019 to June 2021 was collected.Excel,IBM SPSS Modeler 25.0,and Cytoscape were used to perform frequency statistics,cluster analysis,and complex network analysis on the case information.Results A total of 334 prescriptions were involved,159 drugs were included.The top three in frequency of four nature of drugs were flat,warm,and cold drugs.The top three drugs in the frequency of five flavors were sweet,bitter,and pungent.The top three meridian frequency were liver,spleen,and kidney meridians.The top four drug pairs with the highest support:Astragali Radix-Odonopsis Radix;Dioscoreae Rhizoma-Euryales Semen;Astragali Radix-Odonopsis Radix,Eucommiae Cortex;Snow In June-Rhei Radix Et Rhizoma.Two drug combinations were obtained by drug cluster analysis.Conclusion In the treatment of chronic renal failure,Professor Zhang Farong takes tonifying spleen and kidney,nourishing liver and kidney,removing blood stasis and removing turbidity as the main treatment methods,takes into account deficiency and excess,the effect is very good.
作者
李美佳
张法荣
胡福茹
季燕
LI Meijia;ZHANG Farong;HU Furu;JI Yan(The First Clinical College,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250000,China;Department of Nephrology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250000,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250000,China;Department of Information,Jinan Second Mental Health Center,Shandong Province,Jinan 250000,China)
出处
《中国医药导报》
CAS
2022年第14期138-141,共4页
China Medical Herald
基金
国家自然基金面上项目(81774251)。
