摘要
血浆D-二聚体是纤维蛋白被纤溶酶降解时产生的特殊交联纤维蛋白衍生物,D-二聚体在妊娠期随孕周增加而增加,传统用于筛查正常人群静脉血栓形成的血浆D-二聚体参考值(≤0.5 mg/L)不适用于妊娠人群。因D-二聚体检测方法及计量单位不统一,目前尚无统一妊娠及产褥期D-二聚体正常参考值,各个地域或实验室,应通过大样本不同孕期血液样本凝血功能检测,建立自己的妊娠期不同孕周的D-二聚体参考值。现有越来越多研究探讨D-二聚体与妊娠静脉血栓栓塞(venous thromboembolism,VTE)、妊娠期高血压疾病(gestational hypertensive disorders,GHD)、妊娠结局间的关联。本文就D-二聚体产生与测量、正常妊娠期D-二聚体参考值、D-二聚体与部分病理妊娠关联进行综述,加深临床医生对妊娠期D-二聚体的认识。
Plasma D-dimer,a special cross-linked fibrin derivative,is produced when fibrin is degraded by plasminase.During pregnancy,D-dimer increases along with the increase of gestational age,and the reference value of plasma D-dimer(≤0.5 mg/L)traditionally used for the screening of venous thrombosis in the normal population is not applicable to the pregnant population.Due to the lack of uniform D-dimer detection methods or measurement units,there is currently no unified D-dimer reference values for pregnancy or puerperium.Each region or laboratory should establish its own pregnancy D-dimer reference value for different gestational weeks through blood coagulation function testing of large numbers of samples of different gestational periods.More and more studies have been conducted to investigate the association between D-dimer and venous thromboembolism(VTE)during pregnancy,gestational hypertensive disorders(GHD)and pregnancy outcome.We reviewed,herein,the generation and measurement of Ddimer,the reference values of D-dimer during normal pregnancy,and the association between D-dimer and some pathological pregnancies,intending to help clinicians develop a more thorough understanding of D-dimer during pregnancy.
作者
段炼
何国琳
DUAN Lian;HE Guo-lin(Department of Obstetrics,West China Second University Hospital,Chengdu 610041,China;Key Laboratory of Women and Children’s Disease and Birth Defects of the Ministry of Education,Sichuan University,Chengdu 610041,China)
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2022年第3期543-548,共6页
Journal of Sichuan University(Medical Sciences)
