摘要
目的 分析血清S100钙结合蛋白A12(S100A12)、白细胞介素-17A(IL-17A)对冠状动脉药物洗脱支架(DES)植入术后支架内再狭窄(ISR)的预测价值。方法 选取2020年1-12月于该院接受西罗莫司洗脱支架-经皮冠状动脉介入(PCI)治疗的冠心病患者230例,随访12个月,根据ISR发生情况将冠心病患者分为ISR组及非ISR组。比较2组患者血清S100A12、IL-17A水平。采用Spearman相关分析S100A12、IL-17A与高敏C反应蛋白(hs-CRP)的相关性。采用多因素Logistic回归分析影响冠心病患者DES植入后发生ISR的临床因素。采用受试者工作特征(ROC)曲线分析血清S100A12、IL-17A水平对冠心病患者DES植入后发生ISR的预测价值。结果 2组患者动脉病变数目、靶病变狭窄程度、靶病变长度、支架长度及高密度脂蛋白(HDL-C)、血清尿酸(SUA)、hs-CRP水平比较,差异均有统计学意义(P<0.05)。ISR组患者的血清S100A12、IL-17A水平均明显高于非ISR组患者(P<0.001)。经Spearman相关分析,冠心病患者血清IL-17A、S100A12水平均与hs-CRP呈正相关(r_(s)=0.264、0.151,P<0.05)。经多因素Logistic回归分析,HDL-C水平、SUA水平、靶病变长度及血清S100A12、IL-17A水平均是冠心病患者DES植入后发生ISR的独立影响因素(P<0.05)。经ROC曲线分析,血清S100A12、IL-17A联合预测冠心病患者DES植入后发生ISR的AUC为0.981,灵敏度和特异度分别为88.3%和95.9%,优于二者单项检测。结论 血清S100A12、IL-17A是冠心病患者DES植入后发生ISR的独立影响因素,且在预测ISR风险方面具有可接受的应用价值。
Objective To analyze the predictive value of serum S100 calcium binding protein A12(S100A12)and interleukin-17A(IL-17A)in the in-stent restenosis(ISR)after coronary artery drug-eluting stents(DES)implantation.Methods A total of 230 patients with coronary artery disease(CAD)receiving sirolimus eluting stents-percutaneous coronary intervention(PCI)in this hospital from January to December 2020 were selected.During a 12-month follow-up,according to the occurrence of ISR,the patients were divided into the ISR group and non-ISR group.The serum S100A12 and IL-17A levels were compared between the two groups.The Spearman rank correlation was used to analyze the correlation between S100A12 and IL-17A with high-sensitivity C-reactive protein(hs-CRP).The multivariate Logistic regression and was used to analyze the related clinical factors of ISR occurrence after DES implantation in CAD patients.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum S100A12 and IL-17A levels for ISR occurrence after DES implantation in CAD patients.Results There were statistically significant differences in the number of arterial lesions,stenosis degree of target lesions,length of target lesions,stent length,high-density lipoprotein-cholesterol(HDL-C),serum uric acid(SUA)and hs-CRP between 2 groups(P<0.05).Serum S100A12 and IL-17A levels in the ISR group were significantly higher than those in the non-ISR group(P<0.001).According to the Spearman correlation analysis,serum IL-17A and S100A12 levels were positively correlated with hs-CRP in CAD patients(r_(s)=0.264,0.151,P<0.05).The multivariate Logistic regression analysis showed that HDL-C level,SUA level,target lesion length and serum S100A12 and IL-17A levels were the independent clinical factors affecting the ISR occurrence after DES implantation in CAD patients(P<0.05).The ROC curve analysis showed that the AUC of serum S100A12 and IL-17A combined prediction of ISR occurrence after DES implantation in CAD patients was 0.981,and the sensitivity and specificity were 88.3%and 95.9%,respectively,which were better than the detection of serum S100A12 and IL-17A alone.Conclusion Serum S100A12 and IL-17A were the independent influence factors of ISR occurrence after DES implantation in CAD patients,moreover has the acceptable application value in predicting the risk of ISR.
作者
汤万春
尹永厚
谢瑞
TANG Wanchun;YIN Yonghou;XIE Rui(Department of Cardiovascular Medicine,Second Affiliated Hospital of Baotou Medical College,Baotou,Inner Monglia 014030,China)
出处
《国际检验医学杂志》
CAS
2022年第11期1320-1324,1328,共6页
International Journal of Laboratory Medicine
基金
内蒙古自治区自然科学基金项目(2018MS08140)。
