摘要
目的 探讨血清生存素(Survivin)、可溶性细胞凋亡因子(sFas)、白细胞介素-37(IL-37)水平对脓毒症患者病情及预后的评估价值。方法 选取2015年1月至2020年6月在保定市第二医院接受治疗的116例脓毒症患者作为病例组,根据患者治疗30 d后转归情况将其分为生存组和死亡组。另选取同期在该院体检的80例体检健康者作为对照组。检测并比较各组研究对象血清Survivin、sFas、IL-37水平差异。采用受试者工作特征(ROC)曲线分析血清Survivin、sFas、IL-37对脓毒症患者死亡的预测价值。结果 病例组血清Survivin水平低于对照组,血清sFas、IL-37水平高于对照组,差异均有统计学意义(P<0.05)。不同病情严重程度组血清Survivin、sFas、IL-37水平相比,差异均有统计学意义(P<0.05)。生存组85例,死亡组31例。死亡组血清Survivin水平低于生存组,血清sFas、IL-37水平高于生存组,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,血清Survivin分别与APACHEⅡ评分、SOFA评分呈负相关(r<0,P<0.05),血清sFas、IL-37分别与APACHEⅡ评分、SOFA评分呈正相关(r>0,P<0.05)。ROC曲线结果显示,血清Survivin、sFas、IL-37及3项联合检测预测脓毒症患者死亡的AUC分别为0.786、0.809、0.834和0.905。结论 脓毒症患者血清Survivin水平降低,血清sFas、IL-37水平升高。血清Survivin、sFas、IL-37水平与患者疾病进展、临床结局相关,可作为临床评估脓毒症患者病情变化和预后的血清学指标。
Objective To investigate the evaluation value of serum survivin(Survivin),soluble Fas(sFas)and interleukin-37(IL-37)levels in the disease condition and prognosis of the patients with sepsis.Methods A total of 116 patients with sepsis treated in the Baoding Municipal Second Hospital from January 2015 to June 2020 were selected as the case group and divided into the survival group and death group according to their prognosis after 30 d treatment.In addition,80 healthy people ungoing the physical examination in this hospital during the same period were selected as the control group.The levels of serum Survivin,sFas and IL-37 in each group were detected and compared btween the two groups.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum Survivin,SFAS and IL-37 on the death of patients with sepsis.Results The level of serum Survivin in the case group was lower than that in the control group,the levels of serum sFas and IL-37 were higher than those in the control group,and the differences were statistically significant(P<0.05).There were statistically significant differences in the levels of serum Survivin,sFas,and IL-37 among different severity levels groups(P<0.05).There were 85 cases in the survival group and 31 cases in the death group.The serum Survivin level in the death group was lower than that in the survival group,the levels of serum sFas and IL-37 were higher than those in the survival group,and the differences were statistically significant(P<0.05).The Pearson correlation analysis results showed that serum Survivin was negatively correlated with the APACHEⅡscore and SOFA score(r<0,P<0.05).Serum sFas and IL-37 levels were positively correlated with the APACHEⅡscore and SOFA score(r>0,P<0.05).The results of ROC curve showed that the AUC of serum Survivin,SFAS,IL-37 and their combined detection to predict the death of patients with sepsis were 0.786,0.809,0.834 and 0.905,respectively.Conclusion The level of serum Survivin in patients with sepsis is decreased,and the levels of serum sFas and IL-37 are increased.The levels of serum Survivin,SFAS and IL-37 are significantly correlated with disease progression and clinical outcome of patients,and can be used as a serological indicator for clinical assessment of the disease changes and prognosis of patients with sepsis.
作者
李雪青
李文星
唐英明
颜新彦
LI Xueqing;LI Wenxing;TANG Yingming;YAN Xinyan(Department of Infectious Diseases,Baoding Municipal Second Hospital,Baoding,Hebei 071000,China;Department of Emergency Medicine,Baoding Municipal Second Hospital,Baoding,Hebei 071000,China)
出处
《国际检验医学杂志》
CAS
2022年第11期1334-1337,1341,共5页
International Journal of Laboratory Medicine
基金
河北省中医药管理局中医药类科技计划(2015063)。
