硬脂酰辅酶A去饱和酶1抑制剂治疗卵巢癌的研究进展被引量：2

Stearoyl-CoA desaturase-1 inhibitors in the treatment of ovarian cancer

导出

摘要卵巢癌发病隐匿,早期症状常不典型,多数患者就诊时已处于中晚期,预后较差。硬脂酰辅酶A去饱和酶1(stearoyl-CoA desaturases 1,SCD1)是将饱和脂肪酸转化为单不饱和脂肪酸的限速酶,参与卵巢癌的发生、发展。SCD1抑制剂可抑制卵巢癌细胞增殖、诱导卵巢癌细胞凋亡及铁死亡、抑制卵巢癌细胞腹腔转移、降低化疗药物的耐药性。本文就SCD1的结构与功能、SCD1在卵巢癌中的作用及SCD1抑制剂治疗卵巢癌的可能机制作一综述。 Because of the insidious onset and atypical symptoms of ovarian cancer in early stage,the patients usually are in advanced stage at diagnosis,therefore the prognosis is poor.Stearoyl-CoA desaturase-1(SCD1)is a rate-limiting enzyme that converts saturated fatty acids into monounsaturated fatty acids,and participates in the development and progress of ovarian cancer.SCD1 inhibitors can suppress the proliferation,induce the apoptosis and iron death,inhibit the metastasis in the abdominal cavity,and reduce the resistance of chemotherapy drugs.This paper reviews the research progress of the structure and function of SCD1,the role of SCD1 in ovarian cancer and the potential mechanism of SCD1 inhibitors in the treatment of ovarian cancer.

作者王阳阳张一平张云凤牟婧祎王悦 WANG Yang-yang;ZHANG Yi-ping;ZHANG Yun-feng;MU Jing-yi;WANG Yue(Department of Obstetrics and Gynecology,Zhengzhou University People's Hospital,Henan Provincial People's Hospital,Zhengzhou,Henan 450003,China)

机构地区郑州大学人民医院河南省人民医院妇产科

出处《中华实用诊断与治疗杂志》 2022年第5期524-526,共3页 Journal of Chinese Practical Diagnosis and Therapy

基金河南省国际人才合作项目(GH2019019)。

关键词卵巢癌硬脂酰辅酶A去饱和酶1 硬脂酰辅酶A去饱和酶1抑制剂 ovarian cancer stearoyl-CoA desaturase-1 stearoyl-CoA desaturase 1 inhibitors

分类号 R737.31 [医药卫生—肿瘤]

引文网络
相关文献

参考文献5

1彭琼,朱碧琳.血清人附睾分泌蛋白-4对上皮性卵巢癌的早期诊断价值研究[J].中国实验诊断学,2018,22(4):628-629. 被引量：10
2赵静,张立涛,白云,王泽阳,张雪梅,马春玲.抑制硬脂酰辅酶A去饱和酶1表达对乳腺癌细胞增殖和周期的影响[J].四川大学学报（医学版）,2019,50(4):546-550. 被引量：6
3颜清,杨紫伟,戴锦娜.游离单不饱和脂肪酸对胸腔积液良恶性的鉴别诊断[J].中华实用诊断与治疗杂志,2018,32(8):751-754. 被引量：3
4周程成,陈秀生,周智辉.铁死亡逆转肿瘤细胞化疗药物耐药性的研究进展[J].中华实用诊断与治疗杂志,2019,33(11):1128-1130. 被引量：8
5殷慧婷,张颖,张玲莉.活性氧对卵巢癌上皮-间质转化作用研究进展[J].中华实用诊断与治疗杂志,2016,30(6):537-539. 被引量：4

二级参考文献42

1Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition[J]. Nat Rev Mol Cell Biol, 2014,21(15) :178-196.
2Gao D, Joshi N, Choi H, et al. Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition[J]. Cancer Res,2012,72(6) : 1384-1394.
3Costa A, Scholer-Dahirel A, Mechta-Grigoriou F. The role of reactive oxygen species and metabolism on cancer cells and their microenvironment[J]. Semin Cancer Biol, 2014,25 : 23 32.
4Kim MC, Cui FJ, Kim Y. Hydrogen peroxide promotes epithelial to mesenchymal transition and stemness in human malignant mesothelioma cells [J]. Asian Pac J Cancer Prev, 2013,14(6) : 3625-3630.
5Gao H, Wu X, Simon L, et al. Antioxidants maintain Ecadherin levels to limit Drosophila prohemocyte differentiation [J]. PLoSOne,2014,16(9):e107768.
6Wu Y, Zhou BP. Snail: more than EMT[J]. Cell Adh Migr,2010,4(2):199-203.
7Burton LJ, Barnett P, Smith B, et al. Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells[J].BMC Complement Altern Med, 2014,14 :97.
8Barnett P, Arnold RS, Mezencev R, et al. Snail-mediated regulation of reactive oxygen species in ARCaP human prostate cancer cells[J]. Bioehem Biophys Res Commun, 2011,404 (1) : 34-39.
9Boudreau HE, Casterline BW, Rada B, et al. Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration o{ breast epithelial cells[J]. Free Radic Biol Med, 2012,53 (7) : 1489- 1499.
10Ryoo I, Ha H, Kwak MK. Inhibitory role of the KEAP1- NRF2 pathway in TGFbl-stimulated renal epithelial transition to fibroblastic cells: a modulatory effect on SMAD signaling [J]. PLoS ONE,2014,9(4) :e93265.