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近红外光驱动的纳米光敏剂UCNPs@SiO_(2)@TiO_(2)@MnO_(2)的制备与性能 被引量:2

Preparation of infrared light-triggered nanophotosensitizer UCNPs@SiO_(2)@TiO_(2)@MnO_(2) and their performance properties
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摘要 对NaYF_(4):Yb,Tm@NaGdF_(4):Yb@SiO_(2)@TiO_(2)纳米复合粒子(UST)修饰聚乙烯亚胺并沉积MnO_(2),制备了近红外(NIR)光驱动的球形纳米光敏剂NaYF_(4):Yb,Tm@NaGdF_(4):Yb@SiO_(2)@TiO_(2)-PEI@MnO_(2)(USTM).详细表征了所得产物,并研究了USTM催化H_(2)O_(2)产氧和在NIR光下产生活性氧物种(ROS)的性能.结果表明:随着MnO_(2)负载量的增大,USTM的平均直径逐渐增大,催化H_(2)O_(2)产生O_(2)的能力逐渐增强;MnO_(2)增强了光敏剂在NIR光下氧化降解罗丹明B的能力,当H_(2)O_(2)存在时,USTM产生ROS的能力进一步提高;自由基捕获实验证实USTM在NIR光下产生·OH,h^(+),·O_(2)^(-)和^(1)O_(2)等活性物种.上述结果表明,USTM有望成为一种能响应肿瘤微环境、具有增强ROS产生能力的近红外光驱动纳米光敏剂. NaYF_(4):Yb,Tm@NaGdF_(4):Yb@SiO_(2)@TiO_(2)-PEI@MnO_(2)(USTM),a near-infrared(NIR)light-triggered nanophotosensitizer with spherical morphology,was prepared by modifying the nanocomposite NaYF_(4):Yb,Tm@NaGdF_(4):Yb@SiO_(2)@TiO_(2)(UST)with polyethyleneimine(PEI)and subsequently depositing with MnO_(2).The obtained products were characterized in detail,the ability of USTM to catalyze H_(2)O_(2)to produce O_(2)and to generate reactive oxygen species(ROS)under NIR light irradiation were also studied.The results showed that USTM had a gradually increasing mean diameter and enhanced ability to catalyze H_(2)O_(2)to produce O_(2)with the increase of the MnO_(2)amount.Deposition of MnO_(2)could improve the performance of the nanophotosnsitizer in the degradation of rhodamine B under NIR light irradiation.The ROS production ability of USTM was further elevated in the presence of H_(2)O_(2).Radical trapping experiments confirmed that·OH,h^(+),·O_(2)^(-) and 1O_(2)were the reactive species generated by USTM irradiated by NIR light.The results indicated that USTM could be expected to become a NIR-driven nanophotosensitizer that could respond to tumor microenvironment and would have enhanced ROS generation ability.
作者 曹潇楠 胡静慧 张敏丽 王浩 靳丹丹 朱良亮 陈文雪 宫培军 CAO Xiaonan;HU Jinghui;ZHANG Minli;WANG Hao;JIN Dandan;ZHU Liangliang;CHEN Wenxue;GONG Peijun(Key Laboratory of the Ministry of Education for Advanced Catalysis Materials,Zhejiang Normal University,Jinhua 321004,China)
出处 《浙江师范大学学报(自然科学版)》 CAS 2022年第3期315-322,共8页 Journal of Zhejiang Normal University:Natural Sciences
基金 国家自然科学基金资助项目(21201151) 浙江省公益技术应用研究计划项目(LGF20E020001) 浙江省大学生创新创业训练计划(202010345R118)。
关键词 上转换纳米粒子 二氧化锰 光敏剂 活性氧 光动力治疗 upconversion nanoparticle manganese dioxide photosensitizer reactive oxygen species photodynamic therapy
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