摘要
目的探讨预后营养指数(PNI)对呋喹替尼三线治疗晚期结直肠癌患者疗效的预后分析。方法选取2017年11月至2020年6月华中科技大学同济医学院附属同济医院肿瘤中心消化肿瘤科及荆州市中心医院肿瘤科收治并接受呋喹替尼三线治疗的晚期结直肠癌患者33例,计算PNI、中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)以及淋巴细胞/单核细胞比值(LMR)等营养免疫评估指标。采用Cox比例风险回归模型(简称Cox回归)及Kaplan-Meier曲线Log-rank检验评价相关免疫营养指标对于患者生存的影响。结果根据总生存(OS)期的受试者操作特征曲线(ROC曲线)分析,PNI最佳截止点为46.95;单因素Cox回归分析结果显示,PNI、NLR及LMR是OS的影响因素,多变量Cox分析显示PNI是OS期的独立预后因素。低PNI患者1年生存率为9.894%(95%CI=8.300~23.566),中位总生存(mOS)期为6.700个月(95%CI=5.524~7.876),高PNI患者1年生存率是42.218%(95%CI=22.496~46.378,P<0.05),mOS期为11.400个月(95%CI=6.123~16.677,P<0.05);PNI低的患者中位无进展生存(mPFS)期为2.200个月(95%CI=1.278~3.122);PNI高的患者mPFS期为3.067个月(95%CI=1.095~5.039,P>0.05)。结论PNI可作为呋喹替尼三线治疗晚期结直肠癌患者的生存预后因素。
Objective To investigate the prognostic value of prognostic nutritional index(PNI)in the advanced colorectal cancer patients who received the fruquintinib as third-line therapy.Method From November 2017 to June 2020,33 patients with advanced colorectal cancer were selected from Jingzhou Central Hospital and Tongji Hospital Cancer,Tongji Medical College Affiliated,Huazhong U-niversity of Science and Technology.PNI(prognostic nutritional index),PLR(platelet lymphocyte ratio)and LMR(lymphocyte monocyte ratio)were calculated.Cox proportional hazards regression models and Kaplan-Meier curve and Log rank test were used to evaluate the impact on survival.Result According to receiver operating characteristic(ROC)curves,the cut-off value for PNI was 46.95.The result of univariate analysis showed that PNI,HGB,NLR and LMR were significantly correlated with overall survival(OS).Multivariate analysis showed the PNI was independent prognostic factor of OS.The one-year survival rate and the median overall survival for PNI-low patients were 9.894%(95%CI=8.300-23.566)and 6.700 months(95%CI=5.524-7.876),while the one-year survival rate and the mOS for the PNI-high patients were 42.218%(95%CI=22.496-46.378,P<0.05)and 11.400 months(95%CI=6.123-16.677,P<0.05).The median progression free survival(mPFS)for PNI-low and PNI-high patients were 2.200 months(95%CI=1.278-3.122)and 3.067 months(95%CI=1.095-5.039,P>0.05).Conclusion PNI could be a useful prognostic indicator for advanced colorectal cancer patients who received the fruquintinib as third line treatment.
作者
邱萍
唐曦
徐炎华
庄亮
邱红
戴宇翃
Qiu Ping;Tang Xi;Xu Yanhua;Zhang Liang;Qiu Hong;Dai Yuhong(Department of Oncology,Jingzhou Central Hospital,Yangtze University,Jingzhou 433020,Hubei,China;Department of Digestive Oncology,Tongji Hospital Cancer,Tongji Medical College Affiliated,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China)
出处
《肿瘤代谢与营养电子杂志》
2022年第3期350-356,共7页
Electronic Journal of Metabolism and Nutrition of Cancer
基金
国家自然科学基金面上项目(81372664)。
关键词
结直肠癌
呋喹替尼
预后营养指数
生存预后因素
Colorectal cancer
Fruquintinib
Prognostic nutritional index
Survival prognostic factors
