摘要
目的研究甲状腺激素替代疗法对妊娠合并甲状腺功能减退症孕妇预后的影响。方法抽取2018年2月至2021年1月古交市妇幼保健计划生育服务中心收治的106例妊娠合并甲状腺功能减退症的孕妇作为研究对象,根据治疗情况分为观察组62例和对照组44例。对照组给予常规生活指导,观察组在对照组的基础上给予甲状腺激素替代疗法。比较两组患者治疗前后的甲状腺功能[促甲状腺素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)]、血清总胆固醇(TC)、瘦素(LP)、三酰甘油(TG)、血清叶酸、孕酮、甲状腺过氧化酶抗体(TPOAb)水平和妊娠结局情况。结果治疗后,两组患者TSH、TC、LP、TG水平均下降,且观察组低于对照组(P<0.05);两组患者FT3、FT4水平比较差异未见统计学意义(P>0.05)。治疗后,两组患者血清叶酸、孕酮水平均升高,且观察组高于对照组(P<0.05);两组患者TPOAb水平均降低,且观察组低于对照组(P<0.05)。两组患者妊娠结局情况比较差异未见统计学意义(P>0.05)。结论甲状腺激素替代疗法可明显改善患者的甲状腺功能及TC、LP、TG、血清叶酸、孕酮、TPOAb水平,有利于孕妇的预后。
Objective To study the effects of thyroid hormone replacement therapy on the prognosis of pregnant women with hypothyroidism.Methods One hundred and six pregnant women with hypothyroidism treated in Maternal and Child Health Family Planning Service Center of Gujiao from February 2018 to January 2021 were selected as the research subjects.According to the treatment status,the pregnant women were divided into observation group(62 cases)and control group(44 cases).The control group was given routine life guidance,and the observation group was given thyroid hormone replacement therapy based on the treatment of the control group.The levels of thyroid function,including thyroid-stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4),serum total cholesterol(TC),leptin(LP),triacylglycerol(TG),serum folate,progesterone,thyroid peroxidase antibody(TPOAb)before and after treatment were compared between the two groups,and the pregnancy outcomes were compared between the two groups.Results After treatment,the levels of TSH,TC,LP and TG in the two groups decreased,and the levels in the observation group were lower than those in the control group(P<0.05),and there was no significant difference in the levels of FT3 and FT4 between the two groups(P>0.05).After treatment,the levels of serum folate and progesterone in the two groups increased,while these indexes in the observation group were higher than those in the control group(P<0.05).The level of TPOAb decreased in both groups,and the level of TPOAb in the observation group was lower than that in the control group(P<0.05).There was no significant difference in pregnancy outcomes between the two groups(P>0.05).Conclusions Thyroid hormone replacement therapy can significantly improve the thyroid function and levels of TC,LP,TG,serum folate,progesterone and TPOAb,and it is beneficial to the prognosis of pregnant women.
作者
王予倩
白林蝉
李引仙
Wang Yuqian;Bai Linchan;Li Yinxian(Department of Obstetrics and Gynecology,Maternal and Child Health Family Planning Service Center of Gujiao,Gujiao 030200,China)
出处
《中国实用医刊》
2022年第5期96-99,共4页
Chinese Journal of Practical Medicine
关键词
甲状腺激素
替代疗法
妊娠合并甲减
预后
影响
Thyroid hormones
Replacement therapy
Pregnancy with hypothyroidism
Prognosis
Effects
