摘要
目的:探究高压氧联合有氧运动治疗老年轻度血管性痴呆(mVD)的治疗效果及安全性。方法:选取淄博市中心医院收治的老年m VD患者100例作为研究对象。将患者分为4组,每组各25例。对照组患者采用奥拉西坦治疗,有氧运动组在此基础上联合有氧运动,高压氧组在此基础上联合高压氧,联合组患者在此基础上联合有氧运动和高压氧治疗。比较各组患者治疗前、治疗8周后简易智力状态检查(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、血清磷酸化Tau(P-tau)、尿AD7C-NTP水平变化情况及治疗期间不良反应。结论:奥拉西坦、有氧运动和高压氧均可有效改善老年m VD患者认知功能和P-tau水平,但三者联合应用具有更确切的治疗效果,同时可降低患者尿AD7C-NTP水平,安全性较好。
Objective:To explore the effect and safety of hyperbaric oxygen combined with aerobic exercise in the treatment of senile mild vascular dementia(mVD).Methods:100 elderly mVD patients in Zibo Central Hospital were selected as the research object.Patients were divided into 4 groups with 25 in each group.The control group was treated with olacetam,the aerobic exercise group was combined with aerobic exercise on this basis,the hyperbaric oxygen group was combined with hyperbaric oxygen on this basis,and the combined group was combined with aerobic exercise and hyperbaric oxygen on this basis.The MMSE score,Montreal Cognitive Assessment Scale(MoCA) score,serum phosphorylated Tau(P-Tau),urinary AD7 C-NTP levels and adverse reactions during treatment were compared among all groups before and after treatment for 8 weeks.Conclusion:Olacetam,aerobic exercise and hyperbaric oxygen can effectively improve the cognitive function and P-Tau level of elderly mVD patients,but the combination of the three has a more precise therapeutic effect,and can reduce the urinary AD7 C-NTP level of patients,with good safety.
作者
江玉英
JIANG Yu-ying(Zibo Central Hospital)
出处
《中国标准化》
2022年第8期200-202,共3页
China Standardization
关键词
高压氧联合有氧运动
老年
轻度血管性痴呆
疗效观察标准
hyperbaric oxygen combined with aerobic exercise
old age
mild vascular dementia
observation criteria of curative effect
