摘要
目的 分析盐酸利托君治疗对先兆流产患者血清孕酮(P)、妊娠相关血浆蛋白-A(PAPP-A)、糖类抗原125(CA125)水平及妊娠结局的影响,为临床治疗提供参考依据。方法 回顾性分析2020年1月至2021年1月吴川市妇幼保健计划生育服务中心收治的80例先兆流产患者的临床资料,根据治疗方法不同分为A组(硫酸镁治疗)与B组(硫酸镁+盐酸利托君治疗),每组40例,直至宫缩、阴道流血停止后再持续静脉滴注12 h。比较两组患者宫缩消失时间、阴道出血停止时间、妊娠延长时间,治疗前后血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞介素-17(IL-17)、激素及CA125水平,以及保胎成功率、不良反应发生情况。结果 B组患者宫缩消失时间、阴道出血停止时间均短于A组,妊娠延长时间长于A组;治疗后两组患者血清IL-6、IL-17、CA125水平均低于治疗前,且B组低于A组;而血清IL-10、P、PAPP-A水平均高于治疗前,且B组高于A组;治疗后B组患者保胎成功率高于A组;B组患者不良反应总发生率低于A组(均P<0.05)。结论 盐酸利托君治疗先兆流产可缩短患者宫缩消失、阴道出血停止时间,延长妊娠时间,降低炎性因子水平,改善患者的激素水平,提高保胎成功率,安全性高。
Objective To analyze the effects of Ritodrine Hydrochloride treatment on serum progesterone(P),pregnancy-associated plasma protein-A(PAPP-A),carbohydrate antigen 125(CA125) levels and effects on pregnancy outcomes for threatened miscarriage patients,provide reference for clinical treatment.Methods A retrospective analysis of the clinical data of 80 patients with threatened miscarriage admitted to Wuchuan Maternal and Child Health and Family Planning Service Center from January 2020 to January 2021 was done,according to different treatment methods,they were divided into the group A(Magnesium Sulfate treatment) and the group B(Magnesium Sulfate+Ritodrine Hydrochloride treatment),40 cases in each group,until the uterine contractions and vaginal bleeding stopped,and then continued intravenous drip for 12 h.The time to disappearance of uterine contractions,the time to stop vaginal bleeding,and the time to prolong pregnancy were compared between the two groups,serum levels of interleukin-6(IL-6),interleukin-10(IL-10),interleukin-17(IL-17),hormones and CA125 in the two groups of patients before and after treatment,as well as the success rate of miscarriage protection and the occurrence of adverse reactions in the two groups of patients were compared.Results The disappearance time of uterine contractions and vaginal bleeding in the group B were shorter than those in the group A,and the prolonged pregnancy time was longer than that in the group A;after treatment,the serum levels of IL-6,IL-17 and CA125 in the two groups were lower than those before treatment,and the group B was lower than the group A;after treatment,the serum levels of IL-10,P and PAPP-A in the two groups were higher than those before treatment,the group B was higher than the group A;after treatment,the success rate of abortion in the group B was higher than in the group A;the total incidence of adverse reactions in the group B was lower than in the group A(all P <0.05).Conclusion Ritodrine Hydrochloride in the treatment of threatened miscarriage can shorten the disappearance of uterine contractions and the cessation of vaginal bleeding,prolong the pregnancy time,reduce inflammatory factor levels,improve the patient’s hormone level,and improve the success rate of abortion,with high safety.
作者
吴玲燕
WU Lingyan(Department of Obstetrics and Gynecology,Wuchuan Maternal and Child Health and Family Planning Service Center,Zhanjiang,Guangdong 524500,China)
关键词
先兆流产
利托君
妊娠相关血浆蛋白-A
糖类抗原125
孕酮
雌二醇
Threatened miscarriage
Ritodrine Hydrochloride
pregnancy-associated plasma
protein-A
carbohydrate antigen 125
Progesterone
Estradiol
