摘要
目的探讨布拉氏酵母菌散联合蒙脱石散治疗小儿轮状病毒感染性腹泻的效果及对免疫功能的影响。方法采用随机数字表法将我院2020年2月至2021年2月收治的80例轮状病毒感染性腹泻患儿分为对照组和观察组,每组40例。对照组采用蒙脱石散进行治疗,观察组在对照组基础上联合应用布拉氏酵母菌散。比较两组患者的临床疗效、炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、干扰素-γ(INF-γ)]及免疫功能指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、白细胞分化抗原4阳性(CD4+)/白细胞分化抗原8阳性(CD8+)]水平。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的IL-6、TNF-α、hs-CRP和INF-γ水平均较治疗前降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的IgA、IgG水平及CD4+/CD8+均较治疗前升高,且观察组高于对照组,差异具有统计学意义(P<0.05)。结论布拉氏酵母菌散联合蒙脱石散治疗小儿轮状病毒感染性腹泻的效果显著,能明显降低炎症因子水平,有效改善患儿的免疫功能。
Objective To investigate the effect of Saccharomyces boulardii sachets combined with montmorillonite powder on Rotavirus infectious diarrhea in children and its influence on immune function.Methods Eighty children with Rotavirus infectious diarrhea admitted in our hospital from February 2020 to February 2021 were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with montmorillonite powder,and the observation group was treated with Saccharomyces boulardii sachets on the basis of the control group.The clinical efficacy,inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP),interferon-gamma(INF-γ)],and immune function indexes[immunoglobulin A(IgA),immunoglobulin G(IgG),ratio of cluster of differentiation 4 positive(CD4+)to cluster of differentiation 8 positive(CD8+)]levels were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of IL-6,TNF-α,hs-CRP and INF-γin the two groups were lower than those before treatment,those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of IgA,IgG and CD4+/CD8+in the two groups were higher than those before treatment,those in the observation group were higher than the control group,and the differences were statistically significant(P<0.05).Conclusion Saccharomyces boulardii sachets combined with montmorillonite powder in the treatment of Rotavirus infectious diarrhea in children has remarkable effect,which can significantly reduce the levels of inflammatory factors and effectively improve the immune function of children.
作者
徐秀营
王绍杰
XU Xiuying;WANG Shaojie(Pharmacy Department,Xinyi Maternal and Child Health Care Hospital,Maoming 525300;Pharmacy Department,Xinyi People's Hospital,Maoming 525300,China)
出处
《临床医学研究与实践》
2022年第18期80-82,共3页
Clinical Research and Practice
关键词
轮状病毒感染性腹泻
布拉氏酵母菌散
蒙脱石散
免疫功能
Rotavirus infectious diarrhea
Saccharomyces boulardii sachets
montmorillonite powder
immune function
