摘要
目的探讨血清甲状腺激素(HT)检测在孕期甲状腺疾病(TDDP)中的诊断价值.方法选取天津市北辰医院治疗的118例TDDP患者为研究对象,其中亚甲减组38例、甲减组40例、甲亢组40例,选择健康孕妇40例作为对照组.所有受检者均进行血清HT指标检测,包括游离三碘甲状腺原氨酸(FT3)、三碘甲状腺原氨酸(TT3)、游离甲状腺素(FT4)、总甲状腺素(TT4)、促甲状腺素(TSH).结果甲减组患者的FT3、FT4、TT3、TT4水平均低于对照组,TSH水平高于对照组(P<0.05);甲亢组患者的FT3、FT4、TT3、TT4水平均高于对照组,TSH水平低于对照组(P<0.05);亚甲减组患者TSH水平高于对照组(P<0.05);以血清FT3为参考诊断亚甲减、甲减和甲亢的敏感性分别为78.2%、92.1%及92.5%,特异性为72.3%、93.5%和92.6%.对应ROC曲线下面积AUC分别为0.84、0.91和0.92.亚甲减组、甲减组、甲亢组的不良妊娠结局率分别为28.95%、32.50%、30.00%,均明显高于对照组的10.00%,差异明显(P<0.05).结论不同TDDP类型的血清HT指标差异较大,通过HT检测有利于病情诊断及早期治疗,减少不良妊娠结局.
Objective To investigate the diagnostie value of serum thyroid hormone(HT)in thyroid diseases during pregnaney(TDDP),Methods 118 patients with TDDP treated in our hospital were selected as the research object,including 38 cases in sub hypothyroidism group.40 cases in hypothyoidism group,40 cases in byperthyroidism group and 40 cases in healthy pregnant women as the control group.AlI subjects were tested for serum HT,including free triodothyronine(FT3),triodothyronine(TT3),free thyroxine(FT4),.otal thyroxine(TT4)and thyrotropin(TSH),Results The levels of FT3,FT4,TT3 and TT4 in hypothyroidism group were lower than those in control group,and the level of TSH in hypothyroidism group(P<0.05);the levels of FT3.FT4,TT3 and TT4 in hyperthyroidism group were higher than those in control group.and the level of TSH(P<0.05);the TSH level in hypothyroidism group(P<0.05);the sensitivity of serum FT3 in the diagnosis of hypothyoidism.hypothyoidismn and hyperthyroidism were 78.2%,92.1%and 92.5%rectively,and the speifeity was 72.3%,93.5%and 92.6%.The area AUC under the corresponding ROC curve is 0.84,0.91 and 0.92 respectively.The adverse pregnancy outcome rates of sub hypothyroidism group,hypothyroidism group and hyperthyroidism group were 28.95%32.50%and 30.00%respectively,whieh were significantly higher than 10.00%of the control group(P<0.05). The serum HT indexes of diferent TDDP types are quite diferet.The detection of HT is conducive to the diagnosis and early treatment of the disease and reduce the adverse pregnaney outcome.
作者
肖立娇
Xiao Lijiao(Department of Iaboratory,Tianjin Beichen Hospital,Tianjin 300400)
出处
《首都食品与医药》
2022年第11期87-89,共3页
Capital Food Medicine
关键词
甲状腺激素
孕妇
甲状腺疾病
诊断
Thyroid hormone
pregnant woman
Thyroid diseases
diagnosis
