摘要
抑郁症是精神心理疾病中的一种,机制较复杂,其发病机制尚不完全明确,可能与免疫炎症、神经营养因子(BDNF)、神经递质、海马神经元突触可塑性相关。目前临床上使用的一线抗抑郁药物存在不良反应大、患者依从性差、停药后复发率高等问题;而中医治疗具有不良反应小、患者依从性高等特点。现代医学的抑郁症属中医学“郁病”范畴。四逆散首次记载于汉代张仲景所著《伤寒论》中,其功效有透邪解郁、疏肝理脾。现代研究表明四逆散具有明显的抗抑郁作用,其抗抑郁机制可能与调控5-羟色胺(5-HT)水平、调节神经营养因子、降低炎症免疫反应等有关。对四逆散的抗抑郁机制进行了综述。
Depression is a kind of mental and psychological disease with complex mechanism,and its pathogenesis is not completely clear.It may be related to immune inflammation,neurotrophic factor(BDNF),neurotransmitter,and synaptic plasticity of hippocampal neurons.At present,the first-line antidepressants used in clinical practice have many problems such as large side effects,poor patient compliance and high recurrence rate after drug withdrawal.TCM treatment has the characteristics of small adverse reactions and high compliance of patients.The depressed disease of modern medicine belongs to motherland medicine“depressed disease”category.Sini Powder was first recorded in Treatise on Febrile Diseases(Treatise on Febrile Diseases)written by Zhang Zhongjing in the Han Dynasty.Modern studies have shown that Sini Powder has obvious anti-depression effect,and its anti-depression mechanism may be related to its regulation of 5-hydroxytryptamine(5-HT)level,regulation of neurotrophic factors,and reduction of inflammatory immune response.This paper mainly reviews the anti-depression mechanism of Sini Powder.
作者
黄丽蓉
何乾超
庞东林
邓惠
莫穷泽
Huang Lirong;He Qianchao;Pang Donglin;Deng Hui;Mo Qiongze(The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)
出处
《亚太传统医药》
2022年第6期230-234,共5页
Asia-Pacific Traditional Medicine
基金
广西高等学校高水平创新团队及卓越学者计划(桂教人才(2020)6号)
广西中医药大学“岐黄工程”高层次人才团队培育项目(2018003)。
关键词
四逆散
抑郁症
抗抑郁机制
综述
Sini Powder
Depression
Antidepressant Mechanism
Review
