摘要
急性心肌梗死(acute myocardial infarction, AMI)对心脏结构与功能产生严重的不利影响,这些影响不但存在于缺血梗死区,也存在于非梗死区域。非梗死区的心肌功能障碍广泛存在于心肌梗死患者,非梗死区功能异常也是心肌梗死患者预后的重要预测因子。一系列的临床研究和动物实验结果提示了针对非梗死区心肌对维护心功能的重要性。由此可见,对非梗死区心肌功能障碍的表现、机制和干预方法等的深入研究可为有效保存心肌功能、改善心肌梗死患者长期预后提供新的途径。我们就急性心肌梗死后的非梗死心肌相关的临床研究和动物实验机制研究做一综述,以期为心肌梗死的治疗和新的干预思路研究提供依据和启迪。
Acute myocardial infarction(AMI) can cause dramatic remodeling of the heart function and structure. These effects not only exist in the infarcted area, but also in the non-infarcted area. Myocardial dysfunction in the non-infarcted zone widely exists in patients with myocardial infarction, and the abnormal function of the non-infarcted area is an important predictor for the prognosis of AMI patients. Several related clinical and animal studies have also suggested that the regulation of non-infarcted areas is important to maintain cardiac function. Hence, studies on the manifestation, mechanism, and treatment of myocardial dysfunction in the non-infarcted area can provide valuable insights and guidance for myocardial function preservation in myocardial infarction patients. We reviewed the clinical and animal studies related to non-infarcted myocardium after acute myocardial infarction to provide ideas for the treatment and new intervention ideas of AMI.
作者
吴晗
于波
孙欢
WU Han;YU Bo;SUN Huan(Cardiovascular Medicine,China-Japan Union Hospital Of JiLin University,Changchun 130033,China)
出处
《中国比较医学杂志》
CAS
北大核心
2022年第5期138-146,共9页
Chinese Journal of Comparative Medicine
基金
吉林省科技厅项目(20200403091SF)。
关键词
急性心肌梗死
非梗死区心肌
心功能
acute myocardial infarction
non-infarcted myocardium
cardiac function
