摘要
微囊化技术作为一项发展迅速的新技术,具有精确给药、芯材控释等特点,在生物医药、食品、化工等领域均得到成功应用。海藻酸钠是从海洋藻类提取的功能独特的植物多糖,具有良好的溶解性、成膜性和凝胶性等优势,已被广泛用作微囊的包膜材料。但海藻酸钠微囊易受到基质材料、交联剂和生产工艺参数的影响,性质难以调控,所以微囊的生产仍存在配方不完善、制备工艺不稳定等问题。为解决上述问题,本综述对海藻酸钠的离子交换性、pH敏感性、凝胶特性等性质和微囊制备过程的影响因素进行了总结。论述了海藻酸钠微囊在包封细胞、药物以及精油方面的应用,指出今后的研究方向应集中于改进微囊的制备工艺,探明海藻酸钠成膜机理与机械性能的关系,提高海藻酸钠微囊强度与韧性,继续推进海藻酸钠与其他高分子材料的复配研究,以期扩大海藻酸钠微囊的应用范围,加快海藻酸钠微囊的工业化进程。
Microcapsule technology is a new technology with rapid development, and has been successfully applied in biomedicine, food, chemistry, and other fields for its several advantages, including accurate drug administration and controlled content release. Sodium alginate is a unique plant polysaccharide extracted from marine algae, and has been widely used as microcapsule coating materials owing to its good solubility, good film-forming and gelation performance. However, there are still some problems in the manufacture of sodium alginate microcapsules, such as imperfect formula and unstable preparation process, due to the properties of sodium alginate microcapsules being difficult to control and easily affected by base material, cross-linking agent, and process parameters. In order to solve the above problems, the properties of sodium alginate, such as ion exchangeability, pH susceptibility, gelling characteristics, and influencing factors in the preparation process of microcapsules were summarized in this review, and the application of sodium alginate microcapsules in encapsulating cells, drugs, and essential oil were discussed as well. It is pointed out that the future research direction should focus on improving the preparation process of microcapsules, clarifying the relationship between film-forming mechanism and mechanical properties of sodium alginate gel, enhancing the strength and toughness of sodium alginate microcapsules, and promoting the formulation research of sodium alginate with other polymer materials, thereby expanding the application range of sodium alginate microcapsules and accelerating the industrialization process of sodium alginate microcapsules.
作者
袁晓露
李宝霞
黄雅燕
杨宇成
叶静
张娜
张学勤
郑秉得
肖美添
YUAN Xiaolu;LI Baoxia;HUANG Yayan;YANG Yucheng;YE Jing;ZHANG Na;ZHANG Xueqin;ZHENG Bingde;XIAO Meitian(College of Chemical Engineering,Huaqiao University,Xiamen 361021,Fujian,China;Xiamen Engineering and Technological Research Center for Comprehensive Utilization of Marine Biological Resources,Xiamen 361021,Fujian,China)
出处
《化工进展》
EI
CAS
CSCD
北大核心
2022年第6期3103-3112,共10页
Chemical Industry and Engineering Progress
基金
国家自然科学基金面上项目(22078120)
福建省科技重大专项(2020NZ012013)
福建省高校产学合作重大项目(2018N5008)
福建省引导项目(2019N0012)
福建省科技计划对外合作项目(2020I0018,2021I0016)
厦门市高校科研院所产学研项目(3502Z20203047)
华侨大学科研基金(21BS107)。
关键词
海藻酸钠
微囊化
包封材料
凝胶机理
sodium alginate
microencapsulation
encapsulating materials
gelation mechanism
