摘要
目的研究Kupffer细胞特异性摄取的超声造影(Contrast-Enhanced Ultrasound,CEUS)与增强CT对肝脏肿瘤性病变诊断效能的差异。方法纳入连续入组的66例肝脏肿瘤性病变且行注射用全氟丁烷微球超声造影(Sonazoid-CEUS,S-CEUS)及增强CT检查的患者,观察S-CEUS的成像特点,分别进行两种影像诊断与病理结果的一致性比较,并分析两种影像学方法对肝脏肿瘤性病变良恶性的诊断效能。结果66例患者共112枚病灶,经病理证实恶性84枚、良性28枚。S-CEUS、增强CT对肝脏占位性病变良恶性诊断的准确率分别为86.6%(97/112)、80.4%(90/112),敏感度分别为88.1%(74/84)、85.7%(72/84),特异度分别为82.1%(23/28)、64.3%(18/28)。S-CEUS、增强CT诊断与病理结果进行一致性检验的Kappa值分别为0.663与0.488(P>0.05)。应用ROC曲线对比两种影像学检查的诊断效能,S-CEUS高于增强CT,AUC(95%CI)分别为0.851(0.772~0.911)和0.750(0.659~0.827),具有统计学意义(P=0.021)。结论S-CEUS对肝脏肿瘤性病变的诊断效能高于增强CT。
Objective To study the difference between contrast-enhanced ultrasound(CEUS)based on specific uptake of Kupffer cellsand dynamic CT in focal liver lesions.Methods A total of 66 consecutive patients with focal liver lesions were enrolled who underwent Sonazoid-CEUS(S-CEUS)and dynamic CT examinations were included to observe the imaging characteristics of S-CEUS and compare the consistency of the two imaging diagnoses and pathological results respectively.The diagnostic efficacy of two imaging methods for benign and malignant focal liver lesionswas analyzed.Results Totally,112 liver tumors were detected in all 66 patients,among which 84 were malignant and 28 were benign.The accuracyof S-CEUS and dynamic CT for benign and malignant liver occupyinglesions were 86.6%(97/112)and 80.4%(90/112),the sensitivities were 88.1%(74/84)and 85.7%(72/84),and the specificity were 82.1%(23/28)and 64.3%(18/28)respectively.The Kappa values of S-CEUS,dynamic CT compared with pathological results were 0.663 and 0.488,respectively(P>0.05).ROC curve was applied to compare the diagnostic efficacy of the two imaging examinations.S-CEUS was higher than dynamic CT,and the area under the curve(95%CI)were 0.851(0.772~0.911)and 0.750(0.659~0.827),with statistical significance(P=0.021).Conclusion The diagnostic efficiency of S-CEUS is higher than that of dynamic CT forfocal liver lesions.
作者
李晨
刘媛
许静涌
吴明晓
宋京海
陈剑
戴维德
LI Chen;LIU Yuan;XU Jingyong;WU Mingxiao;SONG Jinghai;CHEN Jian;DAI Weide(department of sonography;department of hepatopancreatobiliary surgery,beijing hospital,national center of gerontology,institute of gerontology,chinese academy of medical sciences,beijing 100730,china)
出处
《中国医疗设备》
2022年第6期97-101,共5页
China Medical Devices
基金
北京医院院级课题(BJ-2021-187)。
