摘要
目的研究C⁃反应蛋白(CRP)、降钙素原(PCT)检测在上尿路结石术后继发感染中的临床意义。方法选取2018年11月至2020年11月黄河水利委员会黄河中心医院83例上尿路结石术后患者,根据术后有无继发感染分为感染组(n=10)和未感染组(n=73)。比较两组术后CRP、PCT水平;分析影响上尿路结石术后继发感染的危险因素;绘制ROC曲线,分析CRP、PCT检测对上尿路结石术后继发感染的预测效能。结果感染组CRP、PCT水平高于未感染组,差异有统计学意义(P<0.05)。肾积水、糖尿病史、留置导尿管、结石大小、手术时间、CRP、PCT为影响上尿路结石术后继发感染的单因素(P<0.05)。肾积水(有)、糖尿病史(有)、留置导尿管(有)、结石大小(≥5 cm)、手术时间(≥60 min)、CRP(>8 mg/L)、PCT(>0.05 ng/mL)为患者术后继发感染的危险因素(P<0.05)。ROC曲线示:CRP、PCT联合检测上尿路结石术后继发感染的AUC为0.928,灵敏度为0.917,特异度为0.945(P<0.05)。结论上尿路结石术后CRP、PCT联合检测有助于早期诊断术后继发感染,对临床工作的进行意义重大。
Objective To study the clinical significance of C⁃reactive protein(CRP)and procalcitonin(PCT)detection in secondary infections after the surgery for upper urinary tract calculi.Methods The clinical data of patients after the surgery with upper urinary calculi in the Yellow River Central Hospital of the Yellow River Conservancy Commission from November 2018 to November 2020 were collected.According to the presence or absence of secondary infection after operation in the clinical data,patients were divided into the infected group(n=10)and the non⁃infected group(n=73).The postoperative CRP and PCT levels of patients in the two groups were compared.The risk factors of secondary infection after upper urinary calculi were analyzed.The ROC curve was drawn to analyze the efficacy of CRP and PCT in predicting the secondary infections after upper urinary calculi.Results The levels of CRP and PCT in the infected group were significantly higher than those in the non⁃infected group,and the difference was statistically significant(P<0.05).Hydrone⁃phrosis,history of diabetes,indwelling urinary catheter,stone size,operation time,CRP,PCT were the sin⁃gle factors that affecting the secondary infections after upper urinary calculi(P<0.05).Hydronephrosis(yes),history of diabetes(yes),indwelling catheter(yes),stone size(≥5 cm),operation time(≥60 min),CRP(>8 mg/L),PCT(>0.05 ng/ml)were risk factors for postoperative infection of patients(P<0.05).The ROC curve showed that the combined detection AUC was 0.928,the sensitivity was 0.917 and the specificity was 0.945(P<0.05).Conclusion Combined detection of CRP and PCT after upper urinary calculi can help early diagnosis of postoperative secondary infections,which is of great significance to clinical work.
作者
唐中山
杨坤
王金垒
TANG Zhongshan;YANG Kun;WANG Jinlei(Department of Urology Surgery,Yellow River Central Hospital of Yellow River Water Conservancy Commission,Zhengzhou,Henan,China,450003)
出处
《分子诊断与治疗杂志》
2022年第5期820-823,共4页
Journal of Molecular Diagnostics and Therapy
基金
河南省医学科技攻关计划项目(2018020803)。
关键词
上尿路结石
继发感染
CRP
PCT
Upper urinary tract calculi
Secondary infection
CRP
PCT
