摘要
目的:探讨慢性硬膜下血肿(CSDH)患者钻孔引流术后应用阿托伐他汀联合地塞米松的临床效果。方法:选取2018年2月-2021年6月福州市长乐区医院收治的行钻孔引流术的84例CSDH患者作为研究对象,按照随机数字表法将其分为单药组(术后予以阿托伐他汀治疗)和联合组(术后予以阿托伐他汀和地塞米松治疗),每组42例。比较两组临床疗效、神经功能、不良反应。结果:联合组总有效率为97.62%,高于单药组的80.95%(P<0.05)。治疗后,两组中国卒中量表评分、脑源性神经营养因子(BDNF)、神经元特异性烯醇化酶(NSE)水平均低于治疗前,且联合组均低于单药组,差异均有统计学意义(P<0.05)。联合组不良反应发生率为4.76%,单药组为2.38%,两组比较差异无统计学意义(P>0.05)。结论:CSDH患者钻孔引流术后予以阿托伐他汀及地塞米松联合治疗效果优良,能改善神经功能,且不增加不良反应,值得神经外科医师参考借鉴。
Objective:To investigate the clinical effect of Atorvastatin combined with Dexamethasone after drilling and drainage in patients with chronic subdural hematoma (CSDH).Method:A total of 84 patients with CSDH who underwent drilling and drainage admitted to Changle District Hospital of Fuzhou City from February 2018 to June 2021 were selected as the objects,they were divided into single-drug group (Atorvastatin after operation) and the combined group (Atorvastatin and Dexamethasone after operation) according to the random number table method,42 cases in each group.The clinical efficacy,neurological function and adverse reactions of two groups were compared.Result:The total effective rate of the combined group was 97.62%,which was higher than 80.95% of the single-drug group (P<0.05).After treatment,Chinese stroke scale scores,brain-derived neurotrophic factor (BDNF) and neuron-specific enolase (NSE) of two groups were lower than those before treatment,the combined group were lower than those of the single-drug group,the differences were statistically significant (P<0.05).The adverse reaction rate of the combined group was 4.76%,compared with 2.38% of the single-drug group,and there was no significant difference (P>0.05).Conclusion:The combined treatment of Atorvastatin and Dexamethasone after drilling and drainage of CSDH patients has excellent clinical effects,it can improve neurological function and without increasing adverse reactions,it is worthy of reference for neurosurgeons.
作者
林铖
LIN Cheng(Changle District Hospital of Fuzhou City,Fuzhou 350200,China)
出处
《中国医学创新》
CAS
2022年第15期38-41,共4页
Medical Innovation of China
关键词
慢性硬膜下血肿
钻孔引流术后
地塞米松
阿托伐他汀
神经功能
Chronic subdural hematoma
After drilling and drainage
Dexamethasone
Atorvastatin
Nerve function
