摘要
目的 对肾癌多层螺旋CT灌注参数与MVD、VEGF和Ki-67的相关性进行分析。方法 回顾分析本院2017年5月至2019年1月收治的47例肾癌患者的临床资料,另选取本院同期体检患者20例作为健康组;对患者影像学表现进行分析,并对不同级肾癌患者与健康组灌注参数进行比较;分析不同级肾癌患者中MVD、VEGE、Ki-67表达关系,以及其和MSCT灌注参数的相关性。结果 与健康组比较,肾癌组中1级,2级患者BF、r BV、Pm、TTP值比较,差异均有统计学意义(P<0.05);不同级肾癌患者中BF、r BV、Pm比差异有统计学意义(P<0.05)。MVD计数随肾癌级别上升逐渐上升(P<0.05),与MVD计数呈正相关性(P<0.05);Ki-67表达也随级别增加而高表达越多,为正相关(P<0.05);VEGF表达随级别增加而增加,但之间比较差异无统计学意义(P>0.05),并无显著性意义(P>0.05)。根据相关性分析显示,MVD、Ki-67与CT灌注BF、r BV、Pm参数呈正相关(P<0.05);VEGE与肾癌患者BF为正相关(P>0.05);TTP与VEGE、Ki-67、MVD表达无相关性(P>0.05)。结论 肾细胞癌多层螺旋CT灌注参数与MVD、VEGF和Ki-67的表达有较好的相关性,可为肾癌患者治疗方案制定以及治疗效果监测等提供新技术。
Objective To analyze the correlation between perfusion parameters of renal carcinoma in multi-slice spiral CT and MVD, VEGF and Ki-67. Methods The clinical data of 47 patients with renal carcinoma admitted from May 2017 to January 2019 in our hospital were retrospectively analyzed. 20 patients with physical examination in our hospital at the same period were selected into the healthy group. The patient’s imaging was analyzed, and the perfusion parameters between patients with different grades of renal carcinoma and patients in healthy group were compared. The relationship between MVD, VEGE and Ki-67 expression of patients with different grades of renal carcinoma and their correlation with Ms CT perfusion parameters were analyzed. Results Compared with the healthy group, the BF, r BV, Pm, and TTP values of patients in grade 1 and grade 2 in renal carcinoma group were compared, and the differences were statistically significant(P<0.05). Ther116e were significant differences in the ratios of BF, r BV and Pm between patients with different grades of renal carcinoma(P<0.05). The MVD count increased gradually with the increasing of grade of renal cancer(P<0.05), and positively correlated with it(P<0.05). The expression of Ki-67 also increased with the increasing of grade,and positively correlated with it(P<0.05). The expression of VEGF increased with the increasing of grade, but the difference was not statistically significant(P>0.05), there was no significant difference(P>0.05). According to the correlation analysis, MVD and Ki-67 were positively correlated with BF, r BV and Pm parameters of CT perfusion(P<0.05);VEGE was positively correlated with BF of patients with renal carcinoma(P>0.05). There was no correlation between TTP and VEGE, Ki-67 and MVD expression(P>0.05). Conclusion The perfusion parameters of renal carcinoma in multi-slice spiral CT have a good correlation with the expression of MVD, VEGF and Ki-67, and can provide new techniques for the treatment of patients with renal cancer and the monitoring of therapeutic effects.
作者
刘春光
王颖
陈红丹
刘学梅
LIU Chun-guang;WANG Ying;CHEN Hong-dan;LIU Xue-mei(Department of Radiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China;Department of Otolaryngology,the Third People's Hospital of Zhengzhou,Zhengzhou 450000,Henan Province,China;Department of Magnetic Resonance,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China;CT Room,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China)
出处
《中国CT和MRI杂志》
2022年第7期115-117,共3页
Chinese Journal of CT and MRI
基金
河南省医学科技攻关计划项目(SBGJ2018039)。
