摘要
果蝇zeste基因增强子同源物2(enhancer of zeste homolog 2,EZH2)是一种组蛋白赖氨酸甲基转移酶(histone lysine methyltransferase,HKMT)。EZH2主要通过调控组蛋白H3第27位赖氨酸(H3K27)甲基化修饰参与肿瘤的发生、发展等一系列恶性生物学行为,在表观遗传修饰过程中发挥重要作用。研究显示EZH2在宫颈癌中过表达,并且与患者的不良预后密切相关。EZH2可以促进宫颈癌的增殖、迁移、侵袭、血管生成、耐药以及免疫逃逸等行为。对EZH2的深入研究有望为宫颈癌提供新的分子靶点,从而有助于宫颈癌的早期诊断、预后评估和靶向治疗。
Enhancer of zeste homolog 2(EZH2)is a kind of histone lysine methyltransferase(HKMT).It participates in the malignant behavior of tumorigenesis and development mainly through regulating the methylation modification of H3K27,which plays an important role in epigenetic modification.The researches show that EZH2 is highly expressed in cervical cancer and it is closely related to the poor prognosis of patients.EZH2 takes part in the proliferation,migration,invasion,angiogenesis,drug resistance and immune escape of cervical cancer.The in-depth study of EZH2 is expected to provide a new therapeutic target for cervical cancer,so as to contribute to the early diagnosis,prognosis evaluation and targeted treatment of cervical cancer.
作者
王昭娣
王悦(审校)
WANG Zhao-di;WANG Yue(Department of Obstetrics and Gynecology,Henan University People′s Hospital,Henan Provincial People′s Hospital,Zhengzhou 450003,China)
出处
《国际妇产科学杂志》
CAS
2022年第3期291-295,共5页
Journal of International Obstetrics and Gynecology
基金
河南省省直医疗机构医疗服务能力提升工程建设项目(豫卫医[2017]66号)
郑州市2020年度科技惠民计划项目(2020KJHM0020)。
关键词
Zeste同源蛋白2增强子
宫颈肿瘤
甲基化
细胞增殖
细胞凋亡
Enhancer of zeste homolog 2 protein
Uterine cervical neoplasms
Methylation
Cell proliferation
Apoptosis
